VAV3

VAV3

Vav 3 oncogene, also known as VAV3, is a human gene.cite web | title = Entrez Gene: VAV3 vav 3 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10451| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: VAV3 vav 3 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10451| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hobert O, Schilling JW, Beckerle MC, "et al." |title=SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. |journal=Oncogene |volume=12 |issue= 7 |pages= 1577–81 |year= 1996 |pmid= 8622875 |doi=
*cite journal | author=Tamma SM, Chirmule N, Yagura H, "et al." |title=CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells. |journal=Blood |volume=90 |issue= 4 |pages= 1588–93 |year= 1997 |pmid= 9269777 |doi=
*cite journal | author=Trenkle T, Welsh J, Jung B, "et al." |title=Non-stoichiometric reduced complexity probes for cDNA arrays. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3883–91 |year= 1998 |pmid= 9705494 |doi=
*cite journal | author=Movilla N, Bustelo XR |title=Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7870–85 |year= 1999 |pmid= 10523675 |doi=
*cite journal | author=Trenkle T, McClelland M, Adlkofer K, Welsh J |title=Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. |journal=Gene |volume=245 |issue= 1 |pages= 139–49 |year= 2000 |pmid= 10713454 |doi=
*cite journal | author=Zeng L, Sachdev P, Yan L, "et al." |title=Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. |journal=Mol. Cell. Biol. |volume=20 |issue= 24 |pages= 9212–24 |year= 2001 |pmid= 11094073 |doi=
*cite journal | author=Inabe K, Ishiai M, Scharenberg AM, "et al." |title=Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. |journal=J. Exp. Med. |volume=195 |issue= 2 |pages= 189–200 |year= 2002 |pmid= 11805146 |doi=
*cite journal | author=Yabana N, Shibuya M |title=Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. |journal=Oncogene |volume=21 |issue= 50 |pages= 7720–9 |year= 2002 |pmid= 12400014 |doi= 10.1038/sj.onc.1205927
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zakaria S, Gomez TS, Savoy DN, "et al." |title=Differential regulation of TCR-mediated gene transcription by Vav family members. |journal=J. Exp. Med. |volume=199 |issue= 3 |pages= 429–34 |year= 2004 |pmid= 14757747 |doi= 10.1084/jem.20031228
*cite journal | author=Pearce AC, Senis YA, Billadeau DD, "et al." |title=Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 53955–62 |year= 2005 |pmid= 15456756 |doi= 10.1074/jbc.M410355200
*cite journal | author=Charvet C, Canonigo AJ, Billadeau DD, Altman A |title=Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15289–99 |year= 2005 |pmid= 15708849 |doi= 10.1074/jbc.M500275200
*cite journal | author=Lyons LS, Burnstein KL |title=Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity. |journal=Mol. Endocrinol. |volume=20 |issue= 5 |pages= 1061–72 |year= 2006 |pmid= 16384856 |doi= 10.1210/me.2005-0346
*cite journal | author=Dong Z, Liu Y, Lu S, "et al." |title=Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. |journal=Mol. Endocrinol. |volume=20 |issue= 10 |pages= 2315–25 |year= 2006 |pmid= 16762975 |doi= 10.1210/me.2006-0048

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • SH2 domain — Pfam box Symbol = SH2 Name = width = 220 caption = SH2 domain of human P56 Lck tyrosine kinase Pfam= PF00017 InterPro= IPR000980 SMART= SH2 PROSITE=PDOC50001 SCOP = 1sha TCDB = OPM family= OPM protein= 1xa6 PDB=PDB3|1k9aB:82 156 PDB3|1jwoA:122… …   Wikipedia

  • Pleckstrin homology domain — Pfam box Symbol = PH Name = width =250 caption =PH domain of tyrosine protein kinase BTK Pfam= PF00169 InterPro= IPR001849 SMART= PH PROSITE=PDOC50003 SCOP = 1dyn TCDB = OPM family= 51 OPM protein= 1pls PDB=PDB3|1dynB:520 625 PDB3|2dynA:520 625… …   Wikipedia

  • C1 domain — Pfam box Symbol = C1 1 Name = Phorbol esters/diacylglycerol binding domain (C1 domain) width =200 caption = C1 domain of PKC delta (1ptr) Middle plane of the lipid bilayer black dots. Boundary of the hydrocarbon core region blue dots (cytoplasmic …   Wikipedia

  • RhoGEF domain — Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1] Identifiers Symbol …   Wikipedia

  • RhoG — (Ras homology Growth related) (or ARGH) is a small ( 21 kDa) monomeric GTP binding protein (G protein), and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G… …   Wikipedia

  • SH2B2 — SH2B adaptor protein 2, also known as SH2B2, is a human gene.cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10603| accessdate = ] PBB Summary… …   Wikipedia

  • ROS1 (gene) — V ros UR2 sarcoma virus oncogene homolog 1 (avian), also known as ROS1, is a human gene.cite web | title = Entrez Gene: ROS1 v ros UR2 sarcoma virus oncogene homolog 1 (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Vav (protein) — Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family. GEF activity is mediated via module of tandem DH PH domains. Vav proteins also appear to… …   Wikipedia

  • Оптический спектр — Солнечный свет после прохождения через треугольную стеклянную призму Спектр (лат. spectrum от лат. spectare  смотреть) в физике  распределение значений физической величины (обычно энергии, частоты или массы), а также графическое представление… …   Википедия

  • Световой спектр — Солнечный свет после прохождения через треугольную стеклянную призму Спектр (лат. spectrum от лат. spectare  смотреть) в физике  распределение значений физической величины (обычно энергии, частоты или массы), а также графическое представление… …   Википедия

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”