DHH (gene)

Desert hedgehog homolog (Drosophila), also known as DHH, is a human gene.cite web | title = Entrez Gene: DHH desert hedgehog homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50846| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.cite web | title = Entrez Gene: DHH desert hedgehog homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50846| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matsui Y |title=Regulation of germ cell death in mammalian gonads. |journal=APMIS |volume=106 |issue= 1 |pages= 142–7; discussion 147–8 |year= 1998 |pmid= 9524572 |doi=
*cite journal | author=Umehara F, Tate G, Itoh K, Osame M |title=Minifascicular neuropathy: a new concept of the human disease caused by desert hedgehog gene mutation. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=48 |issue= 2 |pages= 187–9 |year= 2002 |pmid= 11990454 |doi=
*cite journal | author=Echelard Y, Epstein DJ, St-Jacques B, "et al." |title=Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. |journal=Cell |volume=75 |issue= 7 |pages= 1417–30 |year= 1994 |pmid= 7916661 |doi=
*cite journal | author=Bitgood MJ, Shen L, McMahon AP |title=Sertoli cell signaling by Desert hedgehog regulates the male germline. |journal=Curr. Biol. |volume=6 |issue= 3 |pages= 298–304 |year= 1997 |pmid= 8805249 |doi=
*cite journal | author=Carpenter D, Stone DM, Brush J, "et al." |title=Characterization of two patched receptors for the vertebrate hedgehog protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13630–4 |year= 1998 |pmid= 9811851 |doi=
*cite journal | author=Chuang PT, McMahon AP |title=Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. |journal=Nature |volume=397 |issue= 6720 |pages= 617–21 |year= 1999 |pmid= 10050855 |doi= 10.1038/17611
*cite journal | author=Kamisago M, Kimura M, Furutani Y, "et al." |title=Assignment of human desert hedgehog gene (DHH) to chromosome band 12q13.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 117–8 |year= 2000 |pmid= 10640830 |doi=
*cite journal | author=Tate G, Satoh H, Endo Y, Mitsuya T |title=Assignment of desert hedgehog (DHH) to human chromosome bands 12q12-->q13.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 93–4 |year= 2000 |pmid= 10773676 |doi=
*cite journal | author=Umehara F, Tate G, Itoh K, "et al." |title=A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. |journal=Am. J. Hum. Genet. |volume=67 |issue= 5 |pages= 1302–5 |year= 2000 |pmid= 11017805 |doi=
*cite journal | author=Bak M, Hansen C, Friis Henriksen K, Tommerup N |title=The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 300–3 |year= 2001 |pmid= 11435703 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hori Y, Gu X, Xie X, Kim SK |title=Differentiation of insulin-producing cells from human neural progenitor cells. |journal=PLoS Med. |volume=2 |issue= 4 |pages= e103 |year= 2006 |pmid= 15839736 |doi= 10.1371/journal.pmed.0020103
*cite journal | author=Canto P, Vilchis F, Söderlund D, "et al." |title=A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis. |journal=Mol. Hum. Reprod. |volume=11 |issue= 11 |pages= 833–6 |year= 2006 |pmid= 16390857 |doi= 10.1093/molehr/gah216

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