MutL homolog 3 (E. coli), also known as MLH3, is a human gene.cite web | title = Entrez Gene: MLH3 mutL homolog 3 (E. coli)| url =| accessdate = ]

section_title =
summary_text = This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.cite web | title = Entrez Gene: MLH3 mutL homolog 3 (E. coli)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Sherrington R, Rogaev EI, Liang Y, "et al." |title=Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. |journal=Nature |volume=375 |issue= 6534 |pages= 754–60 |year= 1995 |pmid= 7596406 |doi= 10.1038/375754a0
*cite journal | author=Lipkin SM, Wang V, Jacoby R, "et al." |title=MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. |journal=Nat. Genet. |volume=24 |issue= 1 |pages= 27–35 |year= 2000 |pmid= 10615123 |doi= 10.1038/71643
*cite journal | author=Kondo E, Horii A, Fukushige S |title=The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2. |journal=Nucleic Acids Res. |volume=29 |issue= 8 |pages= 1695–702 |year= 2001 |pmid= 11292842 |doi=
*cite journal | author=Lipkin SM, Wang V, Stoler DL, "et al." |title=Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers. |journal=Hum. Mutat. |volume=17 |issue= 5 |pages= 389–96 |year= 2001 |pmid= 11317354 |doi= 10.1002/humu.1114
*cite journal | author=Wu Y, Berends MJ, Sijmons RH, "et al." |title=A role for MLH3 in hereditary nonpolyposis colorectal cancer. |journal=Nat. Genet. |volume=29 |issue= 2 |pages= 137–8 |year= 2001 |pmid= 11586295 |doi= 10.1038/ng1001-137
*cite journal | author=Santucci-Darmanin S, Neyton S, Lespinasse F, "et al." |title=The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination. |journal=Hum. Mol. Genet. |volume=11 |issue= 15 |pages= 1697–706 |year= 2003 |pmid= 12095912 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hienonen T, Laiho P, Salovaara R, "et al." |title=Little evidence for involvement of MLH3 in colorectal cancer predisposition. |journal=Int. J. Cancer |volume=106 |issue= 2 |pages= 292–6 |year= 2003 |pmid= 12800209 |doi= 10.1002/ijc.11218
*cite journal | author=Lenzi ML, Smith J, Snowden T, "et al." |title=Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes. |journal=Am. J. Hum. Genet. |volume=76 |issue= 1 |pages= 112–27 |year= 2005 |pmid= 15558497 |doi= 10.1086/427268
*cite journal | author=Cannavo E, Marra G, Sabates-Bellver J, "et al." |title=Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. |journal=Cancer Res. |volume=65 |issue= 23 |pages= 10759–66 |year= 2006 |pmid= 16322221 |doi= 10.1158/0008-5472.CAN-05-2528
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Taylor NP, Powell MA, Gibb RK, "et al." |title=MLH3 mutation in endometrial cancer. |journal=Cancer Res. |volume=66 |issue= 15 |pages= 7502–8 |year= 2006 |pmid= 16885347 |doi= 10.1158/0008-5472.CAN-06-0248
*cite journal | author=Liu HX, Li Y, Jiang XD, "et al." |title=Mutation screening of mismatch repair gene Mlh3 in familial esophageal cancer. |journal=World J. Gastroenterol. |volume=12 |issue= 33 |pages= 5281–6 |year= 2007 |pmid= 16981255 |doi=
*cite journal | author=Korhonen MK, Raevaara TE, Lohi H, Nyström M |title=Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC. |journal=Oncol. Rep. |volume=17 |issue= 2 |pages= 351–4 |year= 2007 |pmid= 17203173 |doi=
*cite journal | author=Erdeniz N, Nguyen M, Deschênes SM, Liskay RM |title=Mutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functions. |journal=DNA Repair (Amst.) |volume=6 |issue= 10 |pages= 1463–70 |year= 2007 |pmid= 17567544 |doi= 10.1016/j.dnarep.2007.04.013

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