- ICMT
Isoprenylcysteine carboxyl methyltransferase, also known as ICMT, is a human
gene .cite web | title = Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23463| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.cite web | title = Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23463| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Dai Q, Choy E, Chiu V, "et al." |title=Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 15030–4 |year= 1998 |pmid= 9614111 |doi=
*cite journal | author=Choy E, Chiu VK, Silletti J, "et al." |title=Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. |journal=Cell |volume=98 |issue= 1 |pages= 69–80 |year= 1999 |pmid= 10412982 |doi= 10.1016/S0092-8674(00)80607-8
*cite journal | author=Desrosiers RR, Nguyen QT, Béliveau R |title=The carboxyl methyltransferase modifying G proteins is a metalloenzyme. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 790–7 |year= 1999 |pmid= 10441503 |doi= 10.1006/bbrc.1999.0936
*cite journal | author=Lin X, Antalffy B, Kang D, "et al." |title=Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. |journal=Nat. Neurosci. |volume=3 |issue= 2 |pages= 157–63 |year= 2000 |pmid= 10649571 |doi= 10.1038/72101
*cite journal | author=Van Dessel GA, De Busser HM, Lagrou AR |title=Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 5 |pages= 477–86 |year= 2002 |pmid= 11906819 |doi=
*cite journal | author=Ahmad M, Zhang Y, Zhang Y, "et al." |title=Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=22 |issue= 5 |pages= 759–64 |year= 2002 |pmid= 12006387 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kramer K, Harrington EO, Lu Q, "et al." |title=Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. |journal=Mol. Biol. Cell |volume=14 |issue= 3 |pages= 848–57 |year= 2004 |pmid= 12631708 |doi= 10.1091/mbc.E02-07-0390
*cite journal | author=Winter-Vann AM, Kamen BA, Bergo MO, "et al." |title=Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 11 |pages= 6529–34 |year= 2003 |pmid= 12750467 |doi= 10.1073/pnas.1135239100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bergo MO, Gavino BJ, Hong C, "et al." |title=Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. |journal=J. Clin. Invest. |volume=113 |issue= 4 |pages= 539–50 |year= 2004 |pmid= 14966563 |doi= 10.1172/JCI200418829
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lu Q, Harrington EO, Newton J, "et al." |title=Inhibition of ICMT induces endothelial cell apoptosis through GRP94. |journal=Am. J. Respir. Cell Mol. Biol. |volume=37 |issue= 1 |pages= 20–30 |year= 2007 |pmid= 17347446 |doi= 10.1165/rcmb.2006-0301SMPBB_Controls
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