- AMOT
Angiomotin, also known as AMOT, is a human
gene .cite web | title = Entrez Gene: AMOT angiomotin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=154796| accessdate = ]PBB_Summary
section_title =
summary_text = This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length nature has not been completely determined.cite web | title = Entrez Gene: AMOT angiomotin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=154796| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Troyanovsky B, Levchenko T, Månsson G, "et al." |title=Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. |journal=J. Cell Biol. |volume=152 |issue= 6 |pages= 1247–54 |year= 2001 |pmid= 11257124 |doi=
*cite journal | author=Zetter BR |title=Hold that line. Angiomotin regulates endothelial cell motility. |journal=J. Cell Biol. |volume=152 |issue= 6 |pages= F35–6 |year= 2001 |pmid= 11257132 |doi=
*cite journal | author=Bratt A, Wilson WJ, Troyanovsky B, "et al." |title=Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. |journal=Gene |volume=298 |issue= 1 |pages= 69–77 |year= 2003 |pmid= 12406577 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Levchenko T, Aase K, Troyanovsky B, "et al." |title=Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin. |journal=J. Cell. Sci. |volume=116 |issue= Pt 18 |pages= 3803–10 |year= 2004 |pmid= 12902404 |doi= 10.1242/jcs.00694
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Moreau J, Lord M, Boucher M, "et al." |title=Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing. |journal=Gene |volume=350 |issue= 2 |pages= 137–48 |year= 2005 |pmid= 15804419 |doi= 10.1016/j.gene.2005.02.001
*cite journal | author=Bratt A, Birot O, Sinha I, "et al." |title=Angiomotin regulates endothelial cell-cell junctions and cell motility. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34859–69 |year= 2005 |pmid= 16043488 |doi= 10.1074/jbc.M503915200
*cite journal | author=Ernkvist M, Aase K, Ukomadu C, "et al." |title=p130-angiomotin associates to actin and controls endothelial cell shape. |journal=FEBS J. |volume=273 |issue= 9 |pages= 2000–11 |year= 2006 |pmid= 16640563 |doi= 10.1111/j.1742-4658.2006.05216.x
*cite journal | author=Wells CD, Fawcett JP, Traweger A, "et al." |title=A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. |journal=Cell |volume=125 |issue= 3 |pages= 535–48 |year= 2006 |pmid= 16678097 |doi= 10.1016/j.cell.2006.02.045
*cite journal | author=Holmgren L, Ambrosino E, Birot O, "et al." |title=A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 24 |pages= 9208–13 |year= 2006 |pmid= 16754857 |doi= 10.1073/pnas.0603110103PBB_Controls
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