CPN1

CPN1

Carboxypeptidase N, polypeptide 1, also known as CPN1, is a human gene.cite web | title = Entrez Gene: CPN1 carboxypeptidase N, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1369| accessdate = ]

PBB_Summary
section_title =
summary_text = Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.cite web | title = Entrez Gene: CPN1 carboxypeptidase N, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1369| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matthews KW, Mueller-Ortiz SL, Wetsel RA |title=Carboxypeptidase N: a pleiotropic regulator of inflammation. |journal=Mol. Immunol. |volume=40 |issue= 11 |pages= 785–93 |year= 2004 |pmid= 14687935 |doi=
*cite journal | author=Gebhard W, Schube M, Eulitz M |title=cDNA cloning of kininase 1. |journal=Adv. Exp. Med. Biol. |volume=247B |issue= |pages= 261–4 |year= 1990 |pmid= 2610070 |doi=
*cite journal | author=Gebhard W, Schube M, Eulitz M |title=cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1). |journal=Eur. J. Biochem. |volume=178 |issue= 3 |pages= 603–7 |year= 1989 |pmid= 2912725 |doi=
*cite journal | author=Skidgel RA, Bennett CD, Schilling JW, "et al." |title=Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. |journal=Biochem. Biophys. Res. Commun. |volume=154 |issue= 3 |pages= 1323–9 |year= 1988 |pmid= 3408501 |doi=
*cite journal | author=Hendriks D, Vingron M, Vriend G, "et al." |title=On the specificity of carboxypeptidase N, a comparative study. |journal=Biol. Chem. Hoppe-Seyler |volume=374 |issue= 9 |pages= 843–9 |year= 1994 |pmid= 8267877 |doi=
*cite journal | author=Riley DA, Tan F, Miletich DJ, Skidgel RA |title=Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). |journal=Genomics |volume=50 |issue= 1 |pages= 105–8 |year= 1999 |pmid= 9628828 |doi= 10.1006/geno.1998.5295
*cite journal | author=Sato T, Miwa T, Akatsu H, "et al." |title=Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not. |journal=J. Immunol. |volume=165 |issue= 2 |pages= 1053–8 |year= 2000 |pmid= 10878383 |doi=
*cite journal | author=Campbell WD, Lazoura E, Okada N, Okada H |title=Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. |journal=Microbiol. Immunol. |volume=46 |issue= 2 |pages= 131–4 |year= 2002 |pmid= 11939578 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cao H, Hegele RA |title=DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. |journal=J. Hum. Genet. |volume=48 |issue= 1 |pages= 20–2 |year= 2003 |pmid= 12560874 |doi= 10.1007/s100380300003
*cite journal | author=Shimomura Y, Kawamura T, Komura H, "et al." |title=Modulation of procarboxypeptidase R (ProCPR) activation by complementary peptides to thrombomodulin. |journal=Microbiol. Immunol. |volume=47 |issue= 3 |pages= 241–5 |year= 2003 |pmid= 12725295 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Davis DA, Singer KE, De La Luz Sierra M, "et al." |title=Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. |journal=Blood |volume=105 |issue= 12 |pages= 4561–8 |year= 2005 |pmid= 15718415 |doi= 10.1182/blood-2004-12-4618
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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