PIP4K2A

Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha, also known as PIP5K2A, is a human gene.cite web | title = Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5305| accessdate = ]

PBB_Summary
section_title =
summary_text = Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family.cite web | title = Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5305| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Loijens JC, Boronenkov IV, Parker GJ, Anderson RA |title=The phosphatidylinositol 4-phosphate 5-kinase family. |journal=Adv. Enzyme Regul. |volume=36 |issue= |pages= 115–40 |year= 1996 |pmid= 8869744 |doi=
*cite journal | author=Niiro H, Clark EA |title=Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. |journal=Immunity |volume=19 |issue= 5 |pages= 637–40 |year= 2003 |pmid= 14614850 |doi=
*cite journal | author=Carpenter CL |title=Btk-dependent regulation of phosphoinositide synthesis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 326–9 |year= 2004 |pmid= 15046600 |doi= 10.1042/
*cite journal | author=Tolias KF, Cantley LC, Carpenter CL |title=Rho family GTPases bind to phosphoinositide kinases. |journal=J. Biol. Chem. |volume=270 |issue= 30 |pages= 17656–9 |year= 1995 |pmid= 7629060 |doi=
*cite journal | author=Divecha N, Truong O, Hsuan JJ, "et al." |title=The cloning and sequence of the C isoform of PtdIns4P 5-kinase. |journal=Biochem. J. |volume=309 ( Pt 3) |issue= |pages= 715–9 |year= 1995 |pmid= 7639683 |doi=
*cite journal | author=Boronenkov IV, Anderson RA |title=The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases. |journal=J. Biol. Chem. |volume=270 |issue= 7 |pages= 2881–4 |year= 1995 |pmid= 7852364 |doi=
*cite journal | author=Rameh LE, Tolias KF, Duckworth BC, Cantley LC |title=A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. |journal=Nature |volume=390 |issue= 6656 |pages= 192–6 |year= 1997 |pmid= 9367159 |doi= 10.1038/36621
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rozenvayn N, Flaumenhaft R |title=Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8126–34 |year= 2003 |pmid= 12509423 |doi= 10.1074/jbc.M206493200
*cite journal | author=Saito K, Tolias KF, Saci A, "et al." |title=BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. |journal=Immunity |volume=19 |issue= 5 |pages= 669–78 |year= 2003 |pmid= 14614854 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schwab SG, Knapp M, Sklar P, "et al." |title=Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 9 |pages= 837–46 |year= 2006 |pmid= 16801950 |doi= 10.1038/sj.mp.4001864
*cite journal | author=Bakker SC, Hoogendoorn ML, Hendriks J, "et al." |title=The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia. |journal=Genes Brain Behav. |volume=6 |issue= 2 |pages= 113–9 |year= 2007 |pmid= 17410640 |doi=
*cite journal | author=He Z, Li Z, Shi Y, "et al." |title=The PIP5K2A gene and schizophrenia in the Chinese population--a case-control study. |journal=Schizophrenia Research |volume=94 |issue= 1-3 |pages= 359–65 |year= 2007 |pmid= 17555944 |doi= 10.1016/j.schres.2007.04.013

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