GNMT

Glycine N-methyltransferase, also known as GNMT, is a human gene.cite web | title = Entrez Gene: GNMT glycine N-methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27232| accessdate = ]

PBB_Summary
section_title =
summary_text = Glycine N-methyltransferase (GNMT; EC 2.1.1.20) catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. The enzyme was first described by Blumenstein and Williams (1960) in guinea pig liver. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells. [supplied by OMIM] cite web | title = Entrez Gene: GNMT glycine N-methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27232| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wagner C, Decha-Umphai W, Corbin J |title=Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand. |journal=J. Biol. Chem. |volume=264 |issue= 16 |pages= 9638–42 |year= 1989 |pmid= 2722853 |doi=
*cite journal | author=Mudd SH, Ebert MH, Scriver CR |title=Labile methyl group balances in the human: the role of sarcosine. |journal=Metab. Clin. Exp. |volume=29 |issue= 8 |pages= 707–20 |year= 1980 |pmid= 6157075 |doi=
*cite journal | author=Bhat R, Bresnick E |title=Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor. |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 21221–6 |year= 1997 |pmid= 9261130 |doi=
*cite journal | author=Chen YM, Shiu JY, Tzeng SJ, "et al." |title=Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. |journal=Int. J. Cancer |volume=75 |issue= 5 |pages= 787–93 |year= 1998 |pmid= 9495250 |doi=
*cite journal | author=Chen YM, Chen LY, Wong FH, "et al." |title=Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene. |journal=Genomics |volume=66 |issue= 1 |pages= 43–7 |year= 2000 |pmid= 10843803 |doi= 10.1006/geno.2000.6188
*cite journal | author=Mudd SH, Cerone R, Schiaffino MC, "et al." |title=Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. |journal=J. Inherit. Metab. Dis. |volume=24 |issue= 4 |pages= 448–64 |year= 2002 |pmid= 11596649 |doi=
*cite journal | author=Luka Z, Cerone R, Phillips JA, "et al." |title=Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. |journal=Hum. Genet. |volume=110 |issue= 1 |pages= 68–74 |year= 2002 |pmid= 11810299 |doi= 10.1007/s00439-001-0648-4
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tseng TL, Shih YP, Huang YC, "et al." |title=Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. |journal=Cancer Res. |volume=63 |issue= 3 |pages= 647–54 |year= 2003 |pmid= 12566309 |doi=
*cite journal | author=Møller MT, Samari HR, Fengsrud M, "et al." |title=Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. |journal=Biochem. J. |volume=373 |issue= Pt 2 |pages= 505–13 |year= 2003 |pmid= 12697024 |doi= 10.1042/BJ20030502
*cite journal | author=Luka Z, Wagner C |title=Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1067–72 |year= 2004 |pmid= 14651980 |doi=
*cite journal | author=Augoustides-Savvopoulou P, Luka Z, Karyda S, "et al." |title=Glycine N -methyltransferase deficiency: a new patient with a novel mutation. |journal=J. Inherit. Metab. Dis. |volume=26 |issue= 8 |pages= 745–59 |year= 2004 |pmid= 14739680 |doi= 10.1023/B:BOLI.0000009978.17777.33
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Beagle B, Yang TL, Hung J, "et al." |title=The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. |journal=J. Nutr. |volume=135 |issue= 12 |pages= 2780–5 |year= 2006 |pmid= 16317120 |doi=
*cite journal | author=Luka Z, Pakhomova S, Luka Y, "et al." |title=Destabilization of human glycine N-methyltransferase by H176N mutation. |journal=Protein Sci. |volume=16 |issue= 9 |pages= 1957–64 |year= 2007 |pmid= 17660255 |doi= 10.1110/ps.072921507

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