HIP2

Huntingtin interacting protein 2, also known as HIP2, is a human gene.cite web | title = Entrez Gene: HIP2 huntingtin interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.cite web | title = Entrez Gene: HIP2 huntingtin interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Petersén A, Mani K, Brundin P |title=Recent advances on the pathogenesis of Huntington's disease. |journal=Exp. Neurol. |volume=157 |issue= 1 |pages= 1–18 |year= 1999 |pmid= 10222105 |doi= 10.1006/exnr.1998.7006
*cite journal | author=Kalchman MA, Graham RK, Xia G, "et al." |title=Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. |journal=J. Biol. Chem. |volume=271 |issue= 32 |pages= 19385–94 |year= 1996 |pmid= 8702625 |doi=
*cite journal | author=Coux O, Goldberg AL |title=Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8820–8 |year= 1998 |pmid= 9535861 |doi=
*cite journal | author=Whitby FG, Xia G, Pickart CM, Hill CP |title=Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34983–91 |year= 1999 |pmid= 9857030 |doi=
*cite journal | author=Kikuchi J, Furukawa Y, Kubo N, "et al." |title=Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=20 |issue= 1 |pages= 128–34 |year= 2000 |pmid= 10634809 |doi=
*cite journal | author=Furukawa Y, Kubo N, Kikuchi J, "et al." |title=Regulation of macrophage-specific gene expression by degenerated lipoproteins. |journal=Electrophoresis |volume=21 |issue= 2 |pages= 338–46 |year= 2000 |pmid= 10675012 |doi= 10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9 |doilabel=10.1002/(SICI)1522-2683(20000101)21:2338::AID-ELPS3383.0.CO;2-9
*cite journal | author=Lee SJ, Choi JY, Sung YM, "et al." |title=E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. |journal=FEBS Lett. |volume=503 |issue= 1 |pages= 61–4 |year= 2001 |pmid= 11513855 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Flierman D, Coleman CS, Pickart CM, "et al." |title=E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 31 |pages= 11589–94 |year= 2006 |pmid= 16868077 |doi= 10.1073/pnas.0605215103
*cite journal | author=de Pril R, Fischer DF, Roos RA, van Leeuwen FW |title=Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. |journal=Mol. Cell. Neurosci. |volume=34 |issue= 1 |pages= 10–9 |year= 2007 |pmid= 17092742 |doi= 10.1016/j.mcn.2006.09.006
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Christensen DE, Brzovic PS, Klevit RE |title=E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 10 |pages= 941–8 |year= |pmid= 17873885 |doi= 10.1038/nsmb1295

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