ARFGEF1

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited), also known as ARFGEF1, is a human gene.cite web | title = Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10565| accessdate = ]

PBB_Summary
section_title =
summary_text = ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.cite web | title = Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10565| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Morinaga N, Tsai SC, Moss J, Vaughan M |title=Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12856–60 |year= 1996 |pmid= 8917509 |doi=
*cite journal | author=Togawa A, Morinaga N, Ogasawara M, "et al." |title=Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12308–15 |year= 1999 |pmid= 10212200 |doi=
*cite journal | author=Mansour SJ, Skaug J, Zhao XH, "et al." |title=p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 14 |pages= 7968–73 |year= 1999 |pmid= 10393931 |doi=
*cite journal | author=Yamaji R, Adamik R, Takeda K, "et al." |title=Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2567–72 |year= 2000 |pmid= 10716990 |doi=
*cite journal | author=Kamei Y, Takeda Y, Teramoto K, "et al." |title=Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. |journal=Genomics |volume=69 |issue= 1 |pages= 113–9 |year= 2001 |pmid= 11013081 |doi= 10.1006/geno.2000.6310
*cite journal | author=Padilla PI, Chang MJ, Pacheco-Rodriguez G, "et al." |title=Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2322–7 |year= 2003 |pmid= 12606707 |doi= 10.1073/pnas.2628047100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M |title=Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 9 |pages= 2752–7 |year= 2004 |pmid= 14973189 |doi= 10.1073/pnas.0307345101
*cite journal | author=Saeki N, Tokuo H, Ikebe M |title=BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10128–34 |year= 2005 |pmid= 15644318 |doi= 10.1074/jbc.M413415200
*cite journal | author=Citterio C, Jones HD, Pacheco-Rodriguez G, "et al." |title=Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 8 |pages= 2683–8 |year= 2006 |pmid= 16467138 |doi= 10.1073/pnas.0510571103
*cite journal | author=Belov GA, Altan-Bonnet N, Kovtunovych G, "et al." |title=Hijacking components of the cellular secretory pathway for replication of poliovirus RNA. |journal=J. Virol. |volume=81 |issue= 2 |pages= 558–67 |year= 2007 |pmid= 17079330 |doi= 10.1128/JVI.01820-06
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Shen X, Hong MS, Moss J, Vaughan M |title=BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 4 |pages= 1230–5 |year= 2007 |pmid= 17227842 |doi= 10.1073/pnas.0610535104
*cite journal | author=Kuroda F, Moss J, Vaughan M |title=Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 9 |pages= 3201–6 |year= 2007 |pmid= 17360629 |doi= 10.1073/pnas.0611696104

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