WISP2

WNT1 inducible signaling pathway protein 2, also known as WISP2, is a human gene.cite web | title = Entrez Gene: WISP2 WNT1 inducible signaling pathway protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8839| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.cite web | title = Entrez Gene: WISP2 WNT1 inducible signaling pathway protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8839| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pennica D, Swanson TA, Welsh JW, "et al." |title=WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14717–22 |year= 1999 |pmid= 9843955 |doi=
*cite journal | author=Kumar S, Hand AT, Connor JR, "et al." |title=Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17123–31 |year= 1999 |pmid= 10358067 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Saxena N, Banerjee S, Sengupta K, "et al." |title=Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines. |journal=Mol. Cell. Biochem. |volume=228 |issue= 1-2 |pages= 99–104 |year= 2002 |pmid= 11855747 |doi=
*cite journal | author=Inadera H, Dong HY, Matsushima K |title=WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 3 |pages= 602–8 |year= 2002 |pmid= 12056810 |doi= 10.1016/S0006-291X(02)00530-2
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Banerjee S, Saxena N, Sengupta K, "et al." |title=WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation. |journal=Neoplasia |volume=5 |issue= 1 |pages= 63–73 |year= 2003 |pmid= 12659671 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Bourdeau I, Antonini SR, Lacroix A, "et al." |title=Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. |journal=Oncogene |volume=23 |issue= 8 |pages= 1575–85 |year= 2004 |pmid= 14767469 |doi= 10.1038/sj.onc.1207277
*cite journal | author=Mason HR, Lake AC, Wubben JE, "et al." |title=The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells. |journal=Mol. Hum. Reprod. |volume=10 |issue= 3 |pages= 181–7 |year= 2004 |pmid= 14981145 |doi= 10.1093/molehr/gah028
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Banerjee S, Sengupta K, Saxena NK, "et al." |title=Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. |journal=Mol. Cancer Res. |volume=3 |issue= 3 |pages= 151–62 |year= 2005 |pmid= 15798095 |doi= 10.1158/1541-7786.MCR-04-0130
*cite journal | author=Tanaka I, Morikawa M, Okuse T, "et al." |title=Expression and regulation of WISP2 in rheumatoid arthritic synovium. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 4 |pages= 973–8 |year= 2005 |pmid= 16038875 |doi= 10.1016/j.bbrc.2005.06.196
*cite journal | author=Kouzu Y, Uzawa K, Kato M, "et al." |title=WISP-2 expression in human salivary gland tumors. |journal=Int. J. Mol. Med. |volume=17 |issue= 4 |pages= 567–73 |year= 2006 |pmid= 16525711 |doi=
*cite journal | author=Sengupta K, Banerjee S, Dhar K, "et al." |title=WISP-2/CCN5 is involved as a novel signaling intermediate in phorbol ester-protein kinase Calpha-mediated breast tumor cell proliferation. |journal=Biochemistry |volume=45 |issue= 35 |pages= 10698–709 |year= 2006 |pmid= 16939222 |doi= 10.1021/bi060888p
*cite journal | author=Dhar G, Mehta S, Banerjee S, "et al." |title=Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. |journal=Cancer Lett. |volume=254 |issue= 1 |pages= 63–70 |year= 2007 |pmid= 17383817 |doi= 10.1016/j.canlet.2007.02.012
*cite journal | author=Davies SR, Watkins G, Mansel RE, Jiang WG |title=Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. |journal=Ann. Surg. Oncol. |volume=14 |issue= 6 |pages= 1909–18 |year= 2007 |pmid= 17406949 |doi= 10.1245/s10434-007-9376-x

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