WISP3

WNT1 inducible signaling pathway protein 3, also known as WISP3, is a human gene.cite web | title = Entrez Gene: WISP3 WNT1 inducible signaling pathway protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8838| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Alternative splicing generates at least three transcript variants.cite web | title = Entrez Gene: WISP3 WNT1 inducible signaling pathway protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8838| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bork P |title=The modular architecture of a new family of growth regulators related to connective tissue growth factor. |journal=FEBS Lett. |volume=327 |issue= 2 |pages= 125–30 |year= 1993 |pmid= 7687569 |doi=
*cite journal | author=Pennica D, Swanson TA, Welsh JW, "et al." |title=WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14717–22 |year= 1999 |pmid= 9843955 |doi=
*cite journal | author=Hurvitz JR, Suwairi WM, Van Hul W, "et al." |title=Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 94–8 |year= 1999 |pmid= 10471507 |doi= 10.1038/12699
*cite journal | author=Kleer CG, Zhang Y, Pan Q, "et al." |title=WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. |journal=Oncogene |volume=21 |issue= 20 |pages= 3172–80 |year= 2002 |pmid= 12082632 |doi= 10.1038/sj.onc.1205462
*cite journal | author=Tanaka S, Sugimachi K, Shimada M, "et al." |title=Variant WISPs as targets for gastrointestinal carcinomas. |journal=Gastroenterology |volume=123 |issue= 1 |pages= 392–3 |year= 2002 |pmid= 12105881 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Liao EY, Peng YQ, Zhou HD, "et al." |title=Gene symbol: WISP3. Disease: spondyloepihyseal dysplasia tarda with progressive arthropathy. |journal=Hum. Genet. |volume=115 |issue= 2 |pages= 174 |year= 2004 |pmid= 15300987 |doi=
*cite journal | author=Cheon H, Boyle DL, Firestein GS |title=Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. |journal=J. Rheumatol. |volume=31 |issue= 11 |pages= 2106–14 |year= 2005 |pmid= 15517620 |doi=
*cite journal | author=Kutz WE, Gong Y, Warman ML |title=WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. |journal=Mol. Cell. Biol. |volume=25 |issue= 1 |pages= 414–21 |year= 2005 |pmid= 15601861 |doi= 10.1128/MCB.25.1.414-421.2005
*cite journal | author=Cervello M, Giannitrapani L, Labbozzetta M, "et al." |title=Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells. |journal=Ann. N. Y. Acad. Sci. |volume=1028 |issue= |pages= 432–9 |year= 2005 |pmid= 15650268 |doi= 10.1196/annals.1322.051
*cite journal | author=Zhang Y, Pan Q, Zhong H, "et al." |title=Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells. |journal=Breast Cancer Res. |volume=7 |issue= 6 |pages= R1080–9 |year= 2006 |pmid= 16457688 |doi= 10.1186/bcr1351
*cite journal | author=Davis L, Chen Y, Sen M |title=WISP-3 functions as a ligand and promotes superoxide dismutase activity. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 259–65 |year= 2006 |pmid= 16480948 |doi= 10.1016/j.bbrc.2006.01.132
*cite journal | author=Miller DS, Sen M |title=Potential role of WISP3 (CCN6) in regulating the accumulation of reactive oxygen species. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 1 |pages= 156–61 |year= 2007 |pmid= 17286957 |doi= 10.1016/j.bbrc.2007.01.114
*cite journal | author=Yang Y, Liao E |title=Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). |journal=Med. Hypotheses |volume=68 |issue= 6 |pages= 1406–10 |year= 2007 |pmid= 17363178 |doi= 10.1016/j.mehy.2006.06.046
*cite journal | author=Davies SR, Watkins G, Mansel RE, Jiang WG |title=Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. |journal=Ann. Surg. Oncol. |volume=14 |issue= 6 |pages= 1909–18 |year= 2007 |pmid= 17406949 |doi= 10.1245/s10434-007-9376-x

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