ZP2

Zona pellucida glycoprotein 2 (sperm receptor), also known as ZP2, is a human gene.cite web | title = Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7783| accessdate = ]

PBB_Summary
section_title =
summary_text = The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.cite web | title = Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7783| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rankin T, Dean J |title=The zona pellucida: using molecular genetics to study the mammalian egg coat. |journal=Rev. Reprod. |volume=5 |issue= 2 |pages= 114–21 |year= 2000 |pmid= 10864856 |doi=
*cite journal | author=Mori T, Guo MW, Sato E, "et al." |title=Molecular and immunological approaches to mammalian fertilization. |journal=J. Reprod. Immunol. |volume=47 |issue= 2 |pages= 139–58 |year= 2000 |pmid= 10924747 |doi=
*cite journal | author=Liang LF, Dean J |title=Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. |journal=Dev. Biol. |volume=156 |issue= 2 |pages= 399–408 |year= 1993 |pmid= 8385033 |doi= 10.1006/dbio.1993.1087
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Tsubamoto H, Hasegawa A, Nakata Y, "et al." |title=Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. |journal=Biol. Reprod. |volume=61 |issue= 6 |pages= 1649–54 |year= 1999 |pmid= 10570015 |doi=
*cite journal | author=Howes E, Pascall JC, Engel W, Jones R |title=Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. |journal=J. Cell. Sci. |volume=114 |issue= Pt 22 |pages= 4127–36 |year= 2002 |pmid= 11739644 |doi=
*cite journal | author=Tanii I, Oh-oka T, Yoshinaga K, Toshimori K |title=A mouse acrosomal cortical matrix protein, MC41, has ZP2-binding activity and forms a complex with a 75-kDa serine protease. |journal=Dev. Biol. |volume=238 |issue= 2 |pages= 332–41 |year= 2002 |pmid= 11784014 |doi= 10.1006/dbio.2001.0380
*cite journal | author=Kiefer SM, Saling P |title=Proteolytic processing of human zona pellucida proteins. |journal=Biol. Reprod. |volume=66 |issue= 2 |pages= 407–14 |year= 2002 |pmid= 11804956 |doi=
*cite journal | author=Qi H, Williams Z, Wassarman PM |title=Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. |journal=Mol. Biol. Cell |volume=13 |issue= 2 |pages= 530–41 |year= 2002 |pmid= 11854410 |doi= 10.1091/mbc.01-09-0440
*cite journal | author=Zhao M, Gold L, Ginsberg AM, "et al." |title=Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3111–20 |year= 2002 |pmid= 11940668 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rankin TL, Coleman JS, Epifano O, "et al." |title=Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs. |journal=Dev. Cell |volume=5 |issue= 1 |pages= 33–43 |year= 2003 |pmid= 12852850 |doi=
*cite journal | author=Hinsch E, Groeger S, Oehninger S, Hinsch KD |title=Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. |journal=Theriogenology |volume=60 |issue= 7 |pages= 1331–44 |year= 2003 |pmid= 14511786 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Furlong LI, Harris JD, Vazquez-Levin MH |title=Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. |journal=Fertil. Steril. |volume=83 |issue= 6 |pages= 1780–90 |year= 2006 |pmid= 15950651 |doi= 10.1016/j.fertnstert.2004.12.042
*cite journal | author=Caballero-Campo P, Chirinos M, Fan XJ, "et al." |title=Biological effects of recombinant human zona pellucida proteins on sperm function. |journal=Biol. Reprod. |volume=74 |issue= 4 |pages= 760–8 |year= 2006 |pmid= 16407501 |doi= 10.1095/biolreprod.105.047522

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