UFD1L

Ubiquitin fusion degradation 1 like (yeast), also known as UFD1L, is a human gene.cite web | title = Entrez Gene: UFD1L ubiquitin fusion degradation 1 like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7353| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene forms a complex with two other proteins, NPL4 and VCP, that is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: UFD1L ubiquitin fusion degradation 1 like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7353| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Pizzuti A, Novelli G, Ratti A, "et al." |title=UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome. |journal=Hum. Mol. Genet. |volume=6 |issue= 2 |pages= 259–65 |year= 1997 |pmid= 9063746 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Novelli G, Mari A, Amati F, "et al." |title=Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L). |journal=Biochim. Biophys. Acta |volume=1396 |issue= 2 |pages= 158–62 |year= 1998 |pmid= 9540831 |doi=
*cite journal | author=Yamagishi H, Garg V, Matsuoka R, "et al." |title=A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. |journal=Science |volume=283 |issue= 5405 |pages= 1158–61 |year= 1999 |pmid= 10024240 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Botta A, Tandoi C, Fini G, "et al." |title=Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). |journal=Gene |volume=275 |issue= 1 |pages= 39–46 |year= 2001 |pmid= 11574150 |doi=
*cite journal | author=Amati F, Conti E, Botta A, "et al." |title=Functional characterization of the 5' flanking region of human ubiquitin fusion degradation 1 like gene (UFD1L). |journal=Cell Biochem. Funct. |volume=20 |issue= 2 |pages= 163–70 |year= 2002 |pmid= 11979512 |doi= 10.1002/cbf.966
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Amati F, Condò I, Conti E, "et al." |title=Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies. |journal=Cell Biochem. Funct. |volume=21 |issue= 3 |pages= 263–7 |year= 2004 |pmid= 12910480 |doi= 10.1002/cbf.1021
*cite journal | author=Ye Y, Shibata Y, Yun C, "et al." |title=A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. |journal=Nature |volume=429 |issue= 6994 |pages= 841–7 |year= 2004 |pmid= 15215856 |doi= 10.1038/nature02656
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=McConnell E, Lass A, Wójcik C |title=Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 4 |pages= 1087–90 |year= 2007 |pmid= 17331469 |doi= 10.1016/j.bbrc.2007.02.077
*cite journal | author=Cao J, Wang J, Qi W, "et al." |title=Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. |journal=Cell Metab. |volume=6 |issue= 2 |pages= 115–28 |year= 2007 |pmid= 17681147 |doi= 10.1016/j.cmet.2007.07.002

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