RPL22

Ribosomal protein L22, also known as RPL22, is a human gene.cite web | title = Entrez Gene: RPL22 ribosomal protein L22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6146| accessdate = ]

PBB_Summary
section_title =
summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.cite web | title = Entrez Gene: RPL22 ribosomal protein L22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6146| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=Toczyski DP, Steitz JA |title=EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). |journal=EMBO J. |volume=10 |issue= 2 |pages= 459–66 |year= 1991 |pmid= 1846807 |doi=
*cite journal | author=Fujita Y, Okamoto T, Noshiro M, "et al." |title=A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 2 |pages= 706–13 |year= 1994 |pmid= 8135813 |doi= 10.1006/bbrc.1994.1286
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Le S, Sternglanz R, Greider CW |title=Identification of two RNA-binding proteins associated with human telomerase RNA. |journal=Mol. Biol. Cell |volume=11 |issue= 3 |pages= 999–1010 |year= 2000 |pmid= 10712515 |doi=
*cite journal | author=Shu-Nu C, Lin CH, Lin A |title=An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. |journal=FEBS Lett. |volume=484 |issue= 1 |pages= 22–8 |year= 2000 |pmid= 11056215 |doi=
*cite journal | author=Uechi T, Tanaka T, Kenmochi N |title=A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. |journal=Genomics |volume=72 |issue= 3 |pages= 223–30 |year= 2001 |pmid= 11401437 |doi= 10.1006/geno.2000.6470
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Yoshihama M, Uechi T, Asakawa S, "et al." |title=The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. |journal=Genome Res. |volume=12 |issue= 3 |pages= 379–90 |year= 2002 |pmid= 11875025 |doi= 10.1101/gr.214202
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Chen KC, Chiang HS, Fang CL |title=EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients. |journal=Urol. Int. |volume=74 |issue= 3 |pages= 280–2 |year= 2005 |pmid= 15812220 |doi= 10.1159/000083565
*cite journal | author=Fok V, Mitton-Fry RM, Grech A, Steitz JA |title=Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. |journal=RNA |volume=12 |issue= 5 |pages= 872–82 |year= 2006 |pmid= 16556938 |doi= 10.1261/rna.2339606
*cite journal | author=Nakao K, Mochiki M, Nibu K, "et al." |title=Analysis of prognostic factors of nasopharyngeal carcinoma: impact of in situ hybridization for Epstein-Barr virus encoded small RNA 1. |journal=Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery |volume=134 |issue= 4 |pages= 639–45 |year= 2006 |pmid= 16564389 |doi= 10.1016/j.otohns.2005.11.022

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