FADS1

Fatty acid desaturase 1, also known as FADS1, is a human gene.cite web | title = Entrez Gene: FADS1 fatty acid desaturase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3992| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.cite web | title = Entrez Gene: FADS1 fatty acid desaturase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3992| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Stöhr H, Marquardt A, Rivera A, "et al." |title=A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1. |journal=Genome Res. |volume=8 |issue= 1 |pages= 48–56 |year= 1998 |pmid= 9445487 |doi=
*cite journal | author=Cho HP, Nakamura M, Clarke SD |title=Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 37335–9 |year= 2000 |pmid= 10601301 |doi=
*cite journal | author=Leonard AE, Kelder B, Bobik EG, "et al." |title=cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. |journal=Biochem. J. |volume=347 Pt 3 |issue= |pages= 719–24 |year= 2000 |pmid= 10769175 |doi=
*cite journal | author=Marquardt A, Stöhr H, White K, Weber BH |title=cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. |journal=Genomics |volume=66 |issue= 2 |pages= 175–83 |year= 2000 |pmid= 10860662 |doi= 10.1006/geno.2000.6196
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Brizio C, Galluccio M, Wait R, "et al." |title=Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 1008–16 |year= 2006 |pmid= 16643857 |doi= 10.1016/j.bbrc.2006.04.003
*cite journal | author=Schaeffer L, Gohlke H, Müller M, "et al." |title=Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. |journal=Hum. Mol. Genet. |volume=15 |issue= 11 |pages= 1745–56 |year= 2006 |pmid= 16670158 |doi= 10.1093/hmg/ddl117
*cite journal | author=Ma J, Dempsey AA, Stamatiou D, "et al." |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032
*cite journal | author=Dreesen TD, Adamson AW, Tekle M, "et al." |title=A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=75 |issue= 2 |pages= 97–106 |year= 2006 |pmid= 16846730 |doi= 10.1016/j.plefa.2006.05.001
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Risé P, Ghezzi S, Carissimi R, "et al." |title=Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. |journal=Eur. J. Pharmacol. |volume=571 |issue= 2-3 |pages= 97–105 |year= 2007 |pmid= 17655842 |doi= 10.1016/j.ejphar.2007.06.021

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