BRMS1

Breast cancer metastasis suppressor 1, also known as BRMS1, is a human gene.

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summary_text = This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. [ [http://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene ] ] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Meehan WJ, Welch DR |title=Breast cancer metastasis suppressor 1: update. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 45–50 |year= 2003 |pmid= 12650606 |doi=10.1023/A:1022542519586
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791
*cite journal | author=Seraj MJ, Samant RS, Verderame MF, Welch DR |title=Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. |journal=Cancer Res. |volume=60 |issue= 11 |pages= 2764–9 |year= 2000 |pmid= 10850410 |doi=
*cite journal | author=Samant RS, Debies MT, Shevde LA, "et al." |title=Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). |journal=Int. J. Cancer |volume=97 |issue= 1 |pages= 15–20 |year= 2002 |pmid= 11774238 |doi=10.1002/ijc.1569
*cite journal | author=Shevde LA, Samant RS, Goldberg SF, "et al." |title=Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. |journal=Exp. Cell Res. |volume=273 |issue= 2 |pages= 229–39 |year= 2002 |pmid= 11822878 |doi= 10.1006/excr.2001.5452
*cite journal | author=Janneau JL, Maldonado-Estrada J, Tachdjian G, "et al." |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=10.1210/jc.2002-021093
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Meehan WJ, Samant RS, Hopper JE, "et al." |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1562–9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200
*cite journal | author=Cicek M, Samant RS, Kinter M, "et al." |title=Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells. |journal=Clin. Exp. Metastasis |volume=21 |issue= 2 |pages= 149–57 |year= 2004 |pmid= 15168732 |doi=10.1023/B:CLIN.0000024729.19084.f0
*cite journal | author=Nikolaev AY, Papanikolaou NA, Li M, "et al." |title=Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1216–22 |year= 2004 |pmid= 15451426 |doi= 10.1016/j.bbrc.2004.08.227
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stark AM, Tongers K, Maass N, "et al." |title=Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. |journal=J. Cancer Res. Clin. Oncol. |volume=131 |issue= 3 |pages= 191–8 |year= 2005 |pmid= 15592684 |doi= 10.1007/s00432-004-0629-9
*cite journal | author=DeWald DB, Torabinejad J, Samant RS, "et al." |title=Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells. |journal=Cancer Res. |volume=65 |issue= 3 |pages= 713–7 |year= 2005 |pmid= 15705865 |doi=
*cite journal | author=Cicek M, Fukuyama R, Welch DR, "et al." |title=Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity. |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3586–95 |year= 2005 |pmid= 15867352 |doi= 10.1158/0008-5472.CAN-04-3139
*cite journal | author=Hurst DR, Mehta A, Moore BP, "et al." |title=Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 4 |pages= 1429–35 |year= 2006 |pmid= 16919237 |doi= 10.1016/j.bbrc.2006.08.005
*cite journal | author=Samant RS, Clark DW, Fillmore RA, "et al." |title=Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation. |journal=Mol. Cancer |volume=6 |issue= |pages= 6 |year= 2007 |pmid= 17227585 |doi= 10.1186/1476-4598-6-6
*cite journal | author=Rivera J, Megias D, Bravo J |title=Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1. |journal=J. Proteome Res. |volume=6 |issue= 10 |pages= 4006–18 |year= 2007 |pmid= 17854218 |doi= 10.1021/pr0703167

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