RASGRP3

RAS guanyl releasing protein 3 (calcium and DAG-regulated), also known as RASGRP3, is a human gene.cite web | title = Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000). [supplied by OMIM] cite web | title = Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Lorenzo PS, Kung JW, Bottorff DA, "et al." |title=Phorbol esters modulate the Ras exchange factor RasGRP3. |journal=Cancer Res. |volume=61 |issue= 3 |pages= 943–9 |year= 2001 |pmid= 11221888 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Teixeira C, Stang SL, Zheng Y, "et al." |title=Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. |journal=Blood |volume=102 |issue= 4 |pages= 1414–20 |year= 2003 |pmid= 12730099 |doi= 10.1182/blood-2002-11-3621
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brodie C, Steinhart R, Kazimirsky G, "et al." |title=PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. |journal=Mol. Pharmacol. |volume=66 |issue= 1 |pages= 76–84 |year= 2004 |pmid= 15213298 |doi= 10.1124/mol.66.1.76
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Aiba Y, Oh-hora M, Kiyonaka S, "et al." |title=Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 47 |pages= 16612–7 |year= 2004 |pmid= 15545601 |doi= 10.1073/pnas.0407468101
*cite journal | author=Roberts DM, Anderson AL, Hidaka M, "et al." |title=A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10515–28 |year= 2004 |pmid= 15572660 |doi= 10.1128/MCB.24.24.10515-10528.2004
*cite journal | author=Zheng Y, Liu H, Coughlin J, "et al." |title=Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. |journal=Blood |volume=105 |issue= 9 |pages= 3648–54 |year= 2005 |pmid= 15657177 |doi= 10.1182/blood-2004-10-3916
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Okamura SM, Oki-Idouchi CE, Lorenzo PS |title=The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain. |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 36132–9 |year= 2007 |pmid= 17012239 |doi= 10.1074/jbc.M605093200
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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