- MMRN1
Multimerin 1, also known as MMRN1, is a human
gene .cite web | title = Entrez Gene: MMRN1 multimerin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22915| accessdate = ]PBB_Summary
section_title =
summary_text = Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec/Quebec Platelet Disorder) were found to have a deficiency of platelet multimerin.cite web | title = Entrez Gene: MMRN1 multimerin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22915| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Hayward CP |title=Multimerin: a bench-to-bedside chronology of a unique platelet and endothelial cell protein--from discovery to function to abnormalities in disease. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=20 |issue= 3 |pages= 176–87 |year= 1997 |pmid= 9189649 |doi=
*cite journal | author=Hayward CP, Kelton JG |title=Multimerin. |journal=Curr. Opin. Hematol. |volume=2 |issue= 5 |pages= 339–44 |year= 1998 |pmid= 9372017 |doi=
*cite journal | author=Hayward CP, Hassell JA, Denomme GA, "et al." |title=The cDNA sequence of human endothelial cell multimerin. A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18246–51 |year= 1995 |pmid= 7629143 |doi=
*cite journal | author=Hayward CP, Bainton DF, Smith JW, "et al." |title=Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line. |journal=J. Clin. Invest. |volume=91 |issue= 6 |pages= 2630–9 |year= 1993 |pmid= 8514871 |doi=
*cite journal | author=Hayward CP, Rivard GE, Kane WH, "et al." |title=An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect. |journal=Blood |volume=87 |issue= 12 |pages= 4967–78 |year= 1996 |pmid= 8652809 |doi=
*cite journal | author=Hayward CP, Cramer EM, Song Z, "et al." |title=Studies of multimerin in human endothelial cells. |journal=Blood |volume=91 |issue= 4 |pages= 1304–17 |year= 1998 |pmid= 9454761 |doi=
*cite journal | author=Polgár J, Magnenat E, Wells TN, Clemetson KJ |title=Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms. |journal=Thromb. Haemost. |volume=80 |issue= 4 |pages= 645–8 |year= 1999 |pmid= 9798985 |doi=
*cite journal | author=Torres MD, Van Tuinen P, Kroner PA |title=The human multimerin gene MMRN maps to chromosome 4q22. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 275–7 |year= 2000 |pmid= 10828608 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Jeimy SB, Woram RA, Fuller N, "et al." |title=Identification of the MMRN1 binding region within the C2 domain of human factor V. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51466–71 |year= 2005 |pmid= 15452129 |doi= 10.1074/jbc.M409866200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hayward CP, Fuller N, Zheng S, "et al." |title=Human platelets contain forms of factor V in disulfide-linkage with multimerin. |journal=Thromb. Haemost. |volume=92 |issue= 6 |pages= 1349–57 |year= 2005 |pmid= 15583744 |doi= 10.1267/THRO04061349
*cite journal | author=Lewandrowski U, Moebius J, Walter U, Sickmann A |title=Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. |journal=Mol. Cell Proteomics |volume=5 |issue= 2 |pages= 226–33 |year= 2006 |pmid= 16263699 |doi= 10.1074/mcp.M500324-MCP200
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Adam F, Zheng S, Joshi N, "et al." |title=Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3. |journal=Thromb. Haemost. |volume=94 |issue= 5 |pages= 1004–11 |year= 2006 |pmid= 16363244 |doi= 10.1160/TH05-02-0140PBB_Controls
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