- WDR5
WD repeat domain 5, also known as WDR5, is a human
gene .cite web | title = Entrez Gene: WDR5 WD repeat domain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11091| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.cite web | title = Entrez Gene: WDR5 WD repeat domain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11091| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Gori F, Divieti P, Demay MB |title=Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46515–22 |year= 2002 |pmid= 11551928 |doi= 10.1074/jbc.M105757200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wysocka J, Myers MP, Laherty CD, "et al." |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. |journal=Genes Dev. |volume=17 |issue= 7 |pages= 896–911 |year= 2003 |pmid= 12670868 |doi= 10.1101/gad.252103
*cite journal | author=Gori F, Demay MB |title=BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. |journal=Endocrinology |volume=145 |issue= 3 |pages= 1050–4 |year= 2004 |pmid= 14657013 |doi= 10.1210/en.2003-1314
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yokoyama A, Wang Z, Wysocka J, "et al." |title=Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 13 |pages= 5639–49 |year= 2004 |pmid= 15199122 |doi= 10.1128/MCB.24.13.5639-5649.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Wysocka J, Swigut T, Milne TA, "et al." |title=WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. |journal=Cell |volume=121 |issue= 6 |pages= 859–72 |year= 2005 |pmid= 15960974 |doi= 10.1016/j.cell.2005.03.036
*cite journal | author=Dou Y, Milne TA, Tackett AJ, "et al." |title=Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. |journal=Cell |volume=121 |issue= 6 |pages= 873–85 |year= 2005 |pmid= 15960975 |doi= 10.1016/j.cell.2005.04.031
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gori F, Friedman L, Demay MB |title=Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. |journal=Journal of musculoskeletal & neuronal interactions |volume=5 |issue= 4 |pages= 338–9 |year= 2006 |pmid= 16340128 |doi=
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Ruthenburg AJ, Wang W, Graybosch DM, "et al." |title=Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 704–12 |year= 2006 |pmid= 16829959 |doi= 10.1038/nsmb1119
*cite journal | author=Couture JF, Collazo E, Trievel RC |title=Molecular recognition of histone H3 by the WD40 protein WDR5. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 698–703 |year= 2006 |pmid= 16829960 |doi= 10.1038/nsmb1116
*cite journal | author=Dou Y, Milne TA, Ruthenburg AJ, "et al." |title=Regulation of MLL1 H3K4 methyltransferase activity by its core components. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 713–9 |year= 2006 |pmid= 16878130 |doi= 10.1038/nsmb1128
*cite journal | author=Schuetz A, Allali-Hassani A, Martín F, "et al." |title=Structural basis for molecular recognition and presentation of histone H3 by WDR5. |journal=EMBO J. |volume=25 |issue= 18 |pages= 4245–52 |year= 2006 |pmid= 16946699 |doi= 10.1038/sj.emboj.7601316
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134PBB_Controls
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