CILP

Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase, also known as CILP, is a human gene.cite web | title = Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8483| accessdate = ]

PBB_Summary
section_title =
summary_text = Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.cite web | title = Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8483| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Lorenzo P, Bayliss MT, Heinegård D |title=A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23463–8 |year= 1998 |pmid= 9722583 |doi=
*cite journal | author=Lorenzo P, Neame P, Sommarin Y, Heinegård D |title=Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23469–75 |year= 1998 |pmid= 9722584 |doi=
*cite journal | author=Nakamura I, Okawa A, Ikegawa S, "et al." |title=Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP). |journal=J. Hum. Genet. |volume=44 |issue= 3 |pages= 203–5 |year= 1999 |pmid= 10319588 |doi=
*cite journal | author=Lorenzo P, Aman P, Sommarin Y, Heinegård D |title=The human CILP gene: exon/intron organization and chromosomal mapping. |journal=Matrix Biol. |volume=18 |issue= 5 |pages= 445–54 |year= 2000 |pmid= 10601732 |doi=
*cite journal | author=Tsuruha J, Masuko-Hongo K, Kato T, "et al." |title=Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis. |journal=Arthritis Rheum. |volume=44 |issue= 4 |pages= 838–45 |year= 2001 |pmid= 11315923 |doi= 10.1002/1529-0131(200104)44:4<838::AID-ANR140>3.0.CO;2-C |doilabel=10.1002/1529-0131(200104)44:4838::AID-ANR1403.0.CO;2-C
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hirose J, Ryan LM, Masuda I |title=Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. |journal=Arthritis Rheum. |volume=46 |issue= 12 |pages= 3218–29 |year= 2003 |pmid= 12483726 |doi= 10.1002/art.10632
*cite journal | author=Johnson K, Farley D, Hu SI, Terkeltaub R |title=One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. |journal=Arthritis Rheum. |volume=48 |issue= 5 |pages= 1302–14 |year= 2003 |pmid= 12746903 |doi= 10.1002/art.10927
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Yao Z, Nakamura H, Masuko-Hongo K, "et al." |title=Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice. |journal=Ann. Rheum. Dis. |volume=63 |issue= 3 |pages= 252–8 |year= 2004 |pmid= 14962958 |doi=
*cite journal | author=Du H, Masuko-Hongo K, Nakamura H, "et al." |title=The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes. |journal=Rheumatol. Int. |volume=26 |issue= 1 |pages= 35–41 |year= 2006 |pmid= 15378262 |doi= 10.1007/s00296-004-0497-2
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Seki S, Kawaguchi Y, Chiba K, "et al." |title=A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. |journal=Nat. Genet. |volume=37 |issue= 6 |pages= 607–12 |year= 2005 |pmid= 15864306 |doi= 10.1038/ng1557
*cite journal | author=Mori M, Nakajima M, Mikami Y, "et al." |title=Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 121–7 |year= 2006 |pmid= 16413503 |doi= 10.1016/j.bbrc.2005.12.159
*cite journal | author=Virtanen IM, Song YQ, Cheung KM, "et al." |title=Phenotypic and population differences in the association between CILP and lumbar disc disease. |journal=J. Med. Genet. |volume=44 |issue= 4 |pages= 285–8 |year= 2007 |pmid= 17220213 |doi= 10.1136/jmg.2006.047076

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