SYN2

Synapsin II, also known as SYN2, is a human gene.cite web | title = Entrez Gene: SYN2 synapsin II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6854| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts.cite web | title = Entrez Gene: SYN2 synapsin II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6854| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Südhof TC, Czernik AJ, Kao HT, "et al." |title=Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. |journal=Science |volume=245 |issue= 4925 |pages= 1474–80 |year= 1989 |pmid= 2506642 |doi=
*cite journal | author=Greengard P, Valtorta F, Czernik AJ, Benfenati F |title=Synaptic vesicle phosphoproteins and regulation of synaptic function. |journal=Science |volume=259 |issue= 5096 |pages= 780–5 |year= 1993 |pmid= 8430330 |doi=
*cite journal | author=Petersohn D, Schoch S, Brinkmann DR, Thiel G |title=The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2. |journal=J. Biol. Chem. |volume=270 |issue= 41 |pages= 24361–9 |year= 1995 |pmid= 7592648 |doi=
*cite journal | author=Li L, Chin LS, Greengard P, "et al." |title=Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6. |journal=Genomics |volume=28 |issue= 2 |pages= 365–6 |year= 1996 |pmid= 8530057 |doi= 10.1006/geno.1995.1162
*cite journal | author=Xie Y |title=Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA. |journal=Gene |volume=173 |issue= 2 |pages= 289–90 |year= 1996 |pmid= 8964517 |doi=
*cite journal | author=Hosaka M, Südhof TC |title=Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1425–9 |year= 1998 |pmid= 9430678 |doi=
*cite journal | author=Witke W, Podtelejnikov AV, Di Nardo A, "et al." |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. |journal=EMBO J. |volume=17 |issue= 4 |pages= 967–76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967
*cite journal | author=Hosaka M, Südhof TC |title=Homo- and heterodimerization of synapsins. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16747–53 |year= 1999 |pmid= 10358015 |doi=
*cite journal | author=Porton B, Kao HT, Greengard P |title=Cloning of cDNAs encoding human synapsins IIa and IIb. |journal=DNA Seq. |volume=10 |issue= 1 |pages= 49–54 |year= 2000 |pmid= 10565545 |doi=
*cite journal | author=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. |journal=Neuron |volume=24 |issue= 2 |pages= 377–87 |year= 1999 |pmid= 10571231 |doi=
*cite journal | author=Kao HT, Porton B, Hilfiker S, "et al." |title=Molecular evolution of the synapsin gene family. |journal=J. Exp. Zool. |volume=285 |issue= 4 |pages= 360–77 |year= 2000 |pmid= 10578110 |doi=
*cite journal | author=Spielhaupter C, Schätzl HM |title=PrPC directly interacts with proteins involved in signaling pathways. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44604–12 |year= 2002 |pmid= 11571277 |doi= 10.1074/jbc.M103289200
*cite journal | author=Jaffrey SR, Benfenati F, Snowman AM, "et al." |title=Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 3199–204 |year= 2002 |pmid= 11867766 |doi= 10.1073/pnas.261705799
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Chen Q, He G, Wang XY, "et al." |title=Positive association between synapsin II and schizophrenia. |journal=Biol. Psychiatry |volume=56 |issue= 3 |pages= 177–81 |year= 2004 |pmid= 15271586 |doi= 10.1016/j.biopsych.2004.05.010
*cite journal | author=Chen Q, He G, Qin W, "et al." |title=Family-based association study of synapsin II and schizophrenia. |journal=Am. J. Hum. Genet. |volume=75 |issue= 5 |pages= 873–7 |year= 2005 |pmid= 15449241 |doi= 10.1086/425588

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes