STK3

Serine/threonine kinase 3 (STE20 homolog, yeast), also known as STK3, is a human gene.cite web | title = Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6788| accessdate = ]

PBB_Summary
section_title =
summary_text = Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001). [supplied by OMIM] cite web | title = Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6788| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Creasy CL, Chernoff J |title=Cloning and characterization of a human protein kinase with homology to Ste20. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21695–700 |year= 1995 |pmid= 7665586 |doi=
*cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=
*cite journal | author=Creasy CL, Chernoff J |title=Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. |journal=Gene |volume=167 |issue= 1-2 |pages= 303–6 |year= 1996 |pmid= 8566796 |doi=
*cite journal | author=Bren A, Welch M, Blat Y, Eisenbach M |title=Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10090–3 |year= 1996 |pmid= 8816756 |doi=
*cite journal | author=Taylor LK, Wang HC, Erikson RL |title=Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10099–104 |year= 1996 |pmid= 8816758 |doi=
*cite journal | author=Wang HC, Fecteau KA |title=Detection of a novel quiescence-dependent protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25850–7 |year= 2000 |pmid= 10840030 |doi= 10.1074/jbc.M000818200
*cite journal | author=Lee KK, Ohyama T, Yajima N, "et al." |title=MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19276–85 |year= 2001 |pmid= 11278283 |doi= 10.1074/jbc.M005109200
*cite journal | author=De Souza PM, Kankaanranta H, Michael A, "et al." |title=Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. |journal=Blood |volume=99 |issue= 9 |pages= 3432–8 |year= 2002 |pmid= 11964314 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deng Y, Pang A, Wang JH |title=Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 11760–7 |year= 2003 |pmid= 12554736 |doi= 10.1074/jbc.M211085200
*cite journal | author=Rabizadeh S, Xavier RJ, Ishiguro K, "et al." |title=The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29247–54 |year= 2004 |pmid= 15075335 |doi= 10.1074/jbc.M401699200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=O'Neill E, Rushworth L, Baccarini M, Kolch W |title=Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. |journal=Science |volume=306 |issue= 5705 |pages= 2267–70 |year= 2005 |pmid= 15618521 |doi= 10.1126/science.1103233
*cite journal | author=Chan EH, Nousiainen M, Chalamalasetty RB, "et al." |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445
*cite journal | author=Oh HJ, Lee KK, Song SJ, "et al." |title=Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. |journal=Cancer Res. |volume=66 |issue= 5 |pages= 2562–9 |year= 2006 |pmid= 16510573 |doi= 10.1158/0008-5472.CAN-05-2951
*cite journal | author=Callus BA, Verhagen AM, Vaux DL |title=Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. |journal=FEBS J. |volume=273 |issue= 18 |pages= 4264–76 |year= 2006 |pmid= 16930133 |doi= 10.1111/j.1742-4658.2006.05427.x
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Seidel C, Schagdarsurengin U, Blümke K, "et al." |title=Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. |journal=Mol. Carcinog. |volume=46 |issue= 10 |pages= 865–71 |year= 2007 |pmid= 17538946 |doi= 10.1002/mc.20317
*cite journal | author=Matallanas D, Romano D, Yee K, "et al." |title=RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. |journal=Mol. Cell |volume=27 |issue= 6 |pages= 962–75 |year= 2007 |pmid= 17889669 |doi= 10.1016/j.molcel.2007.08.008

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