PPP1R3A

Protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle), also known as PPP1R3A, is a human gene.cite web | title = Entrez Gene: PPP1R3A protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5506| accessdate = ]

PBB_Summary
section_title =
summary_text = The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit (MIM 176875) and a 124-kD targeting and regulatory subunit, referred to as PP1G by Hansen et al. (1995). PP1G binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase (e.g., MIM 138570) and glycogen phosphorylase kinase (e.g., MIM 306000). Phosphorylation at ser46 of the PP1G subunit in response to insulin increases PP1 activity, while phosphorylation at ser65 in response to adrenaline causes dissociation of the catalytic subunit from the G subunit and inhibits glycogen synthesis. Because of these functions, PP1G was postulated to be involved in noninsulin-dependent diabetes mellitus (NIDDM; MIM 125853) and obesity. [supplied by OMIM] cite web | title = Entrez Gene: PPP1R3A protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5506| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hubbard MJ, Cohen P |title=Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzyme. |journal=Eur. J. Biochem. |volume=186 |issue= 3 |pages= 701–9 |year= 1990 |pmid= 2558013 |doi=
*cite journal | author=Hansen L, Hansen T, Vestergaard H, "et al." |title=A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1313–20 |year= 1995 |pmid= 7581368 |doi=
*cite journal | author=Chen YH, Hansen L, Chen MX, "et al." |title=Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. |journal=Diabetes |volume=43 |issue= 10 |pages= 1234–41 |year= 1994 |pmid= 7926294 |doi=
*cite journal | author=Xia J, Scherer SW, Cohen PT, "et al." |title=A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. |journal=Diabetes |volume=47 |issue= 9 |pages= 1519–24 |year= 1998 |pmid= 9726244 |doi=
*cite journal | author=Berrebi-Bertrand I, Souchet M, Camelin JC, "et al." |title=Biophysical interaction between phospholamban and protein phosphatase 1 regulatory subunit GM. |journal=FEBS Lett. |volume=439 |issue= 3 |pages= 224–30 |year= 1998 |pmid= 9845327 |doi=
*cite journal | author=Walker KS, Watt PW, Cohen P |title=Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo. |journal=FEBS Lett. |volume=466 |issue= 1 |pages= 121–4 |year= 2000 |pmid= 10648825 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wang G, Qian R, Li Q, "et al." |title=The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. |journal=Chin. Med. J. |volume=114 |issue= 12 |pages= 1258–62 |year= 2002 |pmid= 11793847 |doi=
*cite journal | author=Savage DB, Agostini M, Barroso I, "et al." |title=Digenic inheritance of severe insulin resistance in a human pedigree. |journal=Nat. Genet. |volume=31 |issue= 4 |pages= 379–84 |year= 2002 |pmid= 12118251 |doi= 10.1038/ng926
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Lerín C, Montell E, Nolasco T, "et al." |title=Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. |journal=Diabetes |volume=52 |issue= 9 |pages= 2221–6 |year= 2003 |pmid= 12941760 |doi=
*cite journal | author=Alcoser SY, Hara M, Bell GI, Ehrmann DA |title=Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 6 |pages= 2973–6 |year= 2004 |pmid= 15181086 |doi= 10.1210/jc.2003-031189
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hayashida Y, Goi T, Hirono Y, "et al." |title=PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis. |journal=Oncol. Rep. |volume=13 |issue= 6 |pages= 1223–7 |year= 2005 |pmid= 15870946 |doi=
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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