SPA17

Sperm autoantigenic protein 17, also known as SPA17, is a human gene.cite web | title = Entrez Gene: SPA17 sperm autoantigenic protein 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53340| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein present at the cell surface. Studies in rabbit suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbit suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.cite web | title = Entrez Gene: SPA17 sperm autoantigenic protein 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53340| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McLeskey SB, Dowds C, Carballada R, "et al." |title=Molecules involved in mammalian sperm-egg interaction. |journal=Int. Rev. Cytol. |volume=177 |issue= |pages= 57–113 |year= 1997 |pmid= 9378618 |doi=
*cite journal | author=Richardson RT, Yamasaki N, O'Rand MG |title=Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction. |journal=Dev. Biol. |volume=165 |issue= 2 |pages= 688–701 |year= 1994 |pmid= 7525387 |doi= 10.1006/dbio.1994.1285
*cite journal | author=Kong M, Richardson RT, Widgren EE, O'Rand MG |title=Sequence and localization of the mouse sperm autoantigenic protein, Sp17. |journal=Biol. Reprod. |volume=53 |issue= 3 |pages= 579–90 |year= 1995 |pmid= 7578682 |doi=
*cite journal | author=Lea IA, Richardson RT, Widgren EE, O'Rand MG |title=Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 3 |pages= 263–6 |year= 1996 |pmid= 8688458 |doi=
*cite journal | author=Fujita A, Nakamura K, Kato T, "et al." |title=Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. |journal=J. Cell. Sci. |volume=113 ( Pt 1) |issue= |pages= 103–12 |year= 2000 |pmid= 10591629 |doi=
*cite journal | author=Wen Y, Richardson RT, Widgren EE, O'Rand MG |title=Characterization of Sp17: a ubiquitous three domain protein that binds heparin. |journal=Biochem. J. |volume=357 |issue= Pt 1 |pages= 25–31 |year= 2001 |pmid= 11415432 |doi=
*cite journal | author=De Jong A, Buchli R, Robbins D |title=Characterization of sperm protein 17 in human somatic and neoplastic tissue. |journal=Cancer Lett. |volume=186 |issue= 2 |pages= 201–9 |year= 2003 |pmid= 12213290 |doi=
*cite journal | author=Buchli R, De Jong A, Robbins DL |title=Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. |journal=Biochim. Biophys. Acta |volume=1578 |issue= 1-3 |pages= 29–42 |year= 2002 |pmid= 12393185 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Frayne J, Hall L |title=A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding. |journal=Reproduction |volume=124 |issue= 6 |pages= 767–74 |year= 2003 |pmid= 12530914 |doi=
*cite journal | author=Takeoka Y, Kenny TP, Yago H, "et al." |title=Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes. |journal=Dev. Immunol. |volume=9 |issue= 2 |pages= 97–102 |year= 2004 |pmid= 12739786 |doi=
*cite journal | author=Chiriva-Internati M, Wang Z, Pochopien S, "et al." |title=Identification of a sperm protein 17 CTL epitope restricted by HLA-A1. |journal=Int. J. Cancer |volume=107 |issue= 5 |pages= 863–5 |year= 2004 |pmid= 14566839 |doi= 10.1002/ijc.11486
*cite journal | author=Straughn JM, Shaw DR, Guerrero A, "et al." |title=Expression of sperm protein 17 (Sp17) in ovarian cancer. |journal=Int. J. Cancer |volume=108 |issue= 6 |pages= 805–11 |year= 2004 |pmid= 14712480 |doi= 10.1002/ijc.11617
*cite journal | author=Lea IA, Widgren EE, O'Rand MG |title=Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. |journal=Reprod. Biol. Endocrinol. |volume=2 |issue= |pages= 57 |year= 2004 |pmid= 15257753 |doi= 10.1186/1477-7827-2-57
*cite journal | author=Wang Z, Zhang Y, Ramsahoye B, "et al." |title=Sp17 gene expression in myeloma cells is regulated by promoter methylation. |journal=Br. J. Cancer |volume=91 |issue= 8 |pages= 1597–603 |year= 2004 |pmid= 15381930 |doi= 10.1038/sj.bjc.6602160
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gupta G, Sharma R, Chattopadhyay TK, "et al." |title=Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. |journal=Int. J. Cancer |volume=120 |issue= 8 |pages= 1739–47 |year= 2007 |pmid= 17230514 |doi= 10.1002/ijc.22463

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