SPDEF

SAM pointed domain containing ets transcription factor, also known as SPDEF, is a human gene.cite web | title = Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25803| accessdate = ]

PBB_Summary
section_title =
summary_text = PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression. [supplied by OMIM] cite web | title = Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25803| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lance V |title=Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions. |journal=Comparative biochemistry and physiology. A, Comparative physiology |volume=53 |issue= 3 |pages= 285–9 |year= 1976 |pmid= 2437 |doi=
*cite journal | author=Johannessen JV, Finseth I |title=Electron micrographs in five minutes. |journal=Ultrastructural pathology |volume=4 |issue= 1 |pages= 97–100 |year= 1983 |pmid= 6857767 |doi=
*cite journal | author=Oettgen P, Finger E, Sun Z, "et al." |title=PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1216–25 |year= 2000 |pmid= 10625666 |doi=
*cite journal | author=Yamada N, Tamai Y, Miyamoto H, Nozaki M |title=Cloning and expression of the mouse Pse gene encoding a novel Ets family member. |journal=Gene |volume=241 |issue= 2 |pages= 267–74 |year= 2000 |pmid= 10675039 |doi=
*cite journal | author=Chen H, Nandi AK, Li X, Bieberich CJ |title=NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. |journal=Cancer Res. |volume=62 |issue= 2 |pages= 338–40 |year= 2002 |pmid= 11809674 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Thompson HG, Harris JW, Wold BJ, "et al." |title=p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. |journal=Oncogene |volume=22 |issue= 15 |pages= 2322–33 |year= 2003 |pmid= 12700667 |doi= 10.1038/sj.onc.1206325
*cite journal | author=Feldman RJ, Sementchenko VI, Gayed M, "et al." |title=Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. |journal=Cancer Res. |volume=63 |issue= 15 |pages= 4626–31 |year= 2003 |pmid= 12907642 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ghadersohi A, Odunsi K, Lele S, "et al." |title=Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules. |journal=Oncol. Rep. |volume=11 |issue= 2 |pages= 453–8 |year= 2004 |pmid= 14719083 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chen H, Bieberich CJ |title=Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF. |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 168–77 |year= 2005 |pmid= 15523673 |doi= 10.1002/jcb.20297
*cite journal | author=Wang Y, Feng L, Said M, "et al." |title=Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. |journal=Biochemistry |volume=44 |issue= 19 |pages= 7095–106 |year= 2005 |pmid= 15882048 |doi= 10.1021/bi047352t
*cite journal | author=Fowler M, Borazanci E, McGhee L, "et al." |title=RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region. |journal=J. Cell. Biochem. |volume=97 |issue= 1 |pages= 1–17 |year= 2006 |pmid= 16237704 |doi= 10.1002/jcb.20664
*cite journal | author=Gunawardane RN, Sgroi DC, Wrobel CN, "et al." |title=Novel role for PDEF in epithelial cell migration and invasion. |journal=Cancer Res. |volume=65 |issue= 24 |pages= 11572–80 |year= 2006 |pmid= 16357167 |doi= 10.1158/0008-5472.CAN-05-1196
*cite journal | author=Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, "et al." |title=Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors. |journal=Int. J. Gynecol. Pathol. |volume=26 |issue= 1 |pages= 10–5 |year= 2007 |pmid= 17197890 |doi= 10.1097/01.pgp.0000225386.41244.bd
*cite journal | author=Park KS, Korfhagen TR, Bruno MD, "et al." |title=SPDEF regulates goblet cell hyperplasia in the airway epithelium. |journal=J. Clin. Invest. |volume=117 |issue= 4 |pages= 978–88 |year= 2007 |pmid= 17347682 |doi= 10.1172/JCI29176

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