PPM1B

Protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform, also known as PPM1B, is a human gene.cite web | title = Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5495| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.cite web | title = Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5495| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Marley AE, Kline A, Crabtree G, "et al." |title=The cloning expression and tissue distribution of human PP2Cbeta. |journal=FEBS Lett. |volume=431 |issue= 1 |pages= 121–4 |year= 1998 |pmid= 9684878 |doi=
*cite journal | author=Hishiya A, Ohnishi M, Tamura S, Nakamura F |title=Protein phosphatase 2C inactivates F-actin binding of human platelet moesin. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26705–12 |year= 1999 |pmid= 10480873 |doi=
*cite journal | author=Cheng A, Ross KE, Kaldis P, Solomon MJ |title=Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. |journal=Genes Dev. |volume=13 |issue= 22 |pages= 2946–57 |year= 2000 |pmid= 10580002 |doi=
*cite journal | author=Cheng A, Kaldis P, Solomon MJ |title=Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34744–9 |year= 2000 |pmid= 10934208 |doi= 10.1074/jbc.M006210200
*cite journal | author=Hanada M, Ninomiya-Tsuji J, Komaki K, "et al." |title=Regulation of the TAK1 signaling pathway by protein phosphatase 2C. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5753–9 |year= 2001 |pmid= 11104763 |doi= 10.1074/jbc.M007773200
*cite journal | author=Parvari R, Brodyansky I, Elpeleg O, "et al." |title=A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease. |journal=Am. J. Hum. Genet. |volume=69 |issue= 4 |pages= 869–75 |year= 2001 |pmid= 11524703 |doi=
*cite journal | author=Seroussi E, Shani N, Ben-Meir D, "et al." |title=Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta. |journal=J. Mol. Biol. |volume=312 |issue= 3 |pages= 439–51 |year= 2001 |pmid= 11563908 |doi= 10.1006/jmbi.2001.4967
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Prajapati S, Verma U, Yamamoto Y, "et al." |title=Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1739–46 |year= 2004 |pmid= 14585847 |doi= 10.1074/jbc.M306273200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Parvari R, Gonen Y, Alshafee I, "et al." |title=The 2p21 deletion syndrome: characterization of the transcription content. |journal=Genomics |volume=86 |issue= 2 |pages= 195–211 |year= 2005 |pmid= 15913950 |doi= 10.1016/j.ygeno.2005.04.001
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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