ATG4B

ATG4 autophagy related 4 homolog B (S. cerevisiae), also known as ATG4B, is a human gene.cite web | title = Entrez Gene: ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23192| accessdate = ]

PBB_Summary
section_title =
summary_text = Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23192| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Mariño G, Uría JA, Puente XS, "et al." |title=Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3671–8 |year= 2003 |pmid= 12446702 |doi= 10.1074/jbc.M208247200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kabeya Y, Mizushima N, Yamamoto A, "et al." |title=LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 13 |pages= 2805–12 |year= 2005 |pmid= 15169837 |doi= 10.1242/jcs.01131
*cite journal | author=Tanida I, Sou YS, Ezaki J, "et al." |title=HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36268–76 |year= 2004 |pmid= 15187094 |doi= 10.1074/jbc.M401461200
*cite journal | author=Tanida I, Ueno T, Kominami E |title=Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 47704–10 |year= 2005 |pmid= 15355958 |doi= 10.1074/jbc.M407016200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Sugawara K, Suzuki NN, Fujioka Y, "et al." |title=Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40058–65 |year= 2006 |pmid= 16183633 |doi= 10.1074/jbc.M509158200
*cite journal | author=Kumanomidou T, Mizushima T, Komatsu M, "et al." |title=The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. |journal=J. Mol. Biol. |volume=355 |issue= 4 |pages= 612–8 |year= 2006 |pmid= 16325851 |doi= 10.1016/j.jmb.2005.11.018
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Tanida I, Sou YS, Minematsu-Ikeguchi N, "et al." |title=Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. |journal=FEBS J. |volume=273 |issue= 11 |pages= 2553–62 |year= 2006 |pmid= 16704426 |doi= 10.1111/j.1742-4658.2006.05260.x
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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