RAPGEF4

RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4, also known as RAPGEF4, is a human gene.cite web | title = Entrez Gene: RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11069| accessdate = ]

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References

Further reading

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*cite journal | author=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089–106 |year= 2002 |pmid= 12384139 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kawasaki H, Springett GM, Mochizuki N, "et al." |title=A family of cAMP-binding proteins that directly activate Rap1. |journal=Science |volume=282 |issue= 5397 |pages= 2275–9 |year= 1999 |pmid= 9856955 |doi=
*cite journal | author=de Rooij J, Rehmann H, van Triest M, "et al." |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829–36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200
*cite journal | author=Ozaki N, Shibasaki T, Kashima Y, "et al." |title=cAMP-GEFII is a direct target of cAMP in regulated exocytosis. |journal=Nat. Cell Biol. |volume=2 |issue= 11 |pages= 805–11 |year= 2001 |pmid= 11056535 |doi= 10.1038/35041046
*cite journal | author=Coppola T, Magnin-Luthi S, Perret-Menoud V, "et al." |title=Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32756–62 |year= 2001 |pmid= 11438518 |doi= 10.1074/jbc.M100929200
*cite journal | author=Kashima Y, Miki T, Shibasaki T, "et al." |title=Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46046–53 |year= 2002 |pmid= 11598134 |doi= 10.1074/jbc.M108378200
*cite journal | author=Ueno H, Shibasaki T, Iwanaga T, "et al." |title=Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. |journal=Genomics |volume=78 |issue= 1-2 |pages= 91–8 |year= 2002 |pmid= 11707077 |doi= 10.1006/geno.2001.6641
*cite journal | author=Rehmann H, Prakash B, Wolf E, "et al." |title=Structure and regulation of the cAMP-binding domains of Epac2. |journal=Nat. Struct. Biol. |volume=10 |issue= 1 |pages= 26–32 |year= 2007 |pmid= 12469113 |doi= 10.1038/nsb878
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bacchelli E, Blasi F, Biondolillo M, "et al." |title=Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene. |journal=Mol. Psychiatry |volume=8 |issue= 11 |pages= 916–24 |year= 2004 |pmid= 14593429 |doi= 10.1038/sj.mp.4001340
*cite journal | author=Shibasaki T, Sunaga Y, Fujimoto K, "et al." |title=Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7956–61 |year= 2004 |pmid= 14660679 |doi= 10.1074/jbc.M309068200
*cite journal | author=Magiera MM, Gupta M, Rundell CJ, "et al." |title=Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. |journal=Biochem. J. |volume=382 |issue= Pt 3 |pages= 803–10 |year= 2005 |pmid= 15202935 |doi= 10.1042/BJ20040122
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Dupuy AG, L'Hoste S, Cherfils J, "et al." |title=Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac. |journal=Oncogene |volume=24 |issue= 28 |pages= 4509–20 |year= 2005 |pmid= 15856025 |doi= 10.1038/sj.onc.1208647
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Ster J, De Bock F, Guérineau NC, "et al." |title=Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 7 |pages= 2519–24 |year= 2007 |pmid= 17284589 |doi= 10.1073/pnas.0611031104

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  • RasGEF domain — Pfam box Symbol = RasGEF Name = RasGEF domain width = caption = Pfam= PF00617 InterPro= IPR001895 SMART= RasGEF PROSITE = PDOC00594 SCOP = 1bkd TCDB = OPM family= OPM protein= 1xd4 PDB=PDB3|1xd2C:777 963 PDB3|1bkdS:777 963 PDB3|1xdvB:777… …   Wikipedia

  • Cyclic nucleotide-binding domain — Structure of a CAP DNA complex.[1] Identifiers Symbol cNMP b …   Wikipedia

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