PRG4

Proteoglycan 4, also known as PRG4, is a human gene.cite web | title = Entrez Gene: PRG4 proteoglycan 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10216| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is an approximately 345-kD proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. The cDNA encodes a protein of 1,404 amino acids with a somatomedin B homology domain, heparin-binding domains, multiple mucin-like repeats, a hemopexin domain, and an aggregation domain. There are 3 consensus sequences for N-glycosylation and 1 chondroitin sulfate substitution site. The locus for autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome maps to chromosome 1q25-q31. This protein may act as a joint/intimal cell lubricant, and cell overgrowth may be primary to the pathogenesis of this protein.cite web | title = Entrez Gene: PRG4 proteoglycan 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10216| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schumacher BL, Block JA, Schmid TM, "et al." |title=A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage. |journal=Arch. Biochem. Biophys. |volume=311 |issue= 1 |pages= 144–52 |year= 1994 |pmid= 8185311 |doi= 10.1006/abbi.1994.1219
*cite journal | author=Bahabri SA, Suwairi WM, Laxer RM, "et al." |title=The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. |journal=Arthritis Rheum. |volume=41 |issue= 4 |pages= 730–5 |year= 1998 |pmid= 9550484 |doi= 10.1002/1529-0131(199804)41:4<730::AID-ART22>3.0.CO;2-Y |doilabel=10.1002/1529-0131(199804)41:4730::AID-ART223.0.CO;2-Y
*cite journal | author=Flannery CR, Hughes CE, Schumacher BL, "et al." |title=Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 535–41 |year= 1999 |pmid= 9920774 |doi= 10.1006/bbrc.1998.0104
*cite journal | author=Marcelino J, Carpten JD, Suwairi WM, "et al." |title=CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 319–22 |year= 1999 |pmid= 10545950 |doi= 10.1038/15496
*cite journal | author=Jay GD, Britt DE, Cha CJ |title=Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. |journal=J. Rheumatol. |volume=27 |issue= 3 |pages= 594–600 |year= 2000 |pmid= 10743795 |doi=
*cite journal | author=Ikegawa S, Sano M, Koshizuka Y, Nakamura Y |title=Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3-4 |pages= 291–7 |year= 2001 |pmid= 11124536 |doi=
*cite journal | author=Rees SG, Davies JR, Tudor D, "et al." |title=Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. |journal=Matrix Biol. |volume=21 |issue= 7 |pages= 593–602 |year= 2003 |pmid= 12475643 |doi=
*cite journal | author=Morawietz L, Gehrke T, Frommelt L, "et al." |title=Differential gene expression in the periprosthetic membrane: lubricin as a new possible pathogenetic factor in prosthesis loosening. |journal=Virchows Arch. |volume=443 |issue= 1 |pages= 57–66 |year= 2003 |pmid= 12783322 |doi= 10.1007/s00428-003-0818-y
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Liu YJ, Lu SH, Xu B, "et al." |title=Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. |journal=Blood |volume=103 |issue= 12 |pages= 4449–56 |year= 2004 |pmid= 14976050 |doi= 10.1182/blood-2003-06-1825
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=de Haan G |title=A novel growth factor encoded by an old gene. |journal=Haematologica |volume=90 |issue= 2 |pages= 152 |year= 2006 |pmid= 15710563 |doi=
*cite journal | author=Rhee DK, Marcelino J, Al-Mayouf S, "et al." |title=Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 31325–32 |year= 2005 |pmid= 16000300 |doi= 10.1074/jbc.M505401200
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Alazami AM, Al-Mayouf SM, Wyngaard CA, Meyer B |title=Novel PRG4 mutations underlie CACP in Saudi families. |journal=Hum. Mutat. |volume=27 |issue= 2 |pages= 213 |year= 2006 |pmid= 16429407 |doi= 10.1002/humu.9399
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Zhang D, Johnson LJ, Hsu HP, Spector M |title=Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage. |journal=J. Orthop. Res. |volume=25 |issue= 7 |pages= 873–83 |year= 2007 |pmid= 17343281 |doi= 10.1002/jor.20344
*cite journal | author=Jay GD, Torres JR, Warman ML, "et al." |title=The role of lubricin in the mechanical behavior of synovial fluid. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 15 |pages= 6194–9 |year= 2007 |pmid= 17404241 |doi= 10.1073/pnas.0608558104

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