FCN3

FCN3

Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen), also known as FCN3, is a human gene.cite web | title = Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8547| accessdate = ]

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summary_text = Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.cite web | title = Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8547| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yae Y, Inaba S, Sato H, "et al." |title=Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. |journal=Biochim. Biophys. Acta |volume=1078 |issue= 3 |pages= 369–76 |year= 1991 |pmid= 1859827 |doi=
*cite journal | author=Inaba S, Okochi K, Yae Y, "et al." |title=Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system. |journal=Fukuoka Igaku Zasshi |volume=81 |issue= 9 |pages= 284–91 |year= 1991 |pmid= 2276712 |doi=
*cite journal | author=Sugimoto R, Yae Y, Akaiwa M, "et al." |title=Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 20721–7 |year= 1998 |pmid= 9694814 |doi=
*cite journal | author=Akaiwa M, Yae Y, Sugimoto R, "et al." |title=Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. |journal=J. Histochem. Cytochem. |volume=47 |issue= 6 |pages= 777–86 |year= 1999 |pmid= 10330454 |doi=
*cite journal | author=Matsushita M, Kuraya M, Hamasaki N, "et al." |title=Activation of the lectin complement pathway by H-ficolin (Hakata antigen). |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3502–6 |year= 2002 |pmid= 11907111 |doi=
*cite journal | author=Tsujimura M, Miyazaki T, Kojima E, "et al." |title=Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth. |journal=Clin. Chim. Acta |volume=325 |issue= 1-2 |pages= 139–46 |year= 2003 |pmid= 12367778 |doi=
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*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Muzny DM, Scherer SE, Kaul R, "et al." |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728
*cite journal | author=Garlatti V, Belloy N, Martin L, "et al." |title=Structural insights into the innate immune recognition specificities of L- and H-ficolins. |journal=EMBO J. |volume=26 |issue= 2 |pages= 623–33 |year= 2007 |pmid= 17215869 |doi= 10.1038/sj.emboj.7601500
*cite journal | author=Honoré C, Hummelshoj T, Hansen BE, "et al." |title=The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. |journal=Arthritis Rheum. |volume=56 |issue= 5 |pages= 1598–607 |year= 2007 |pmid= 17469142 |doi= 10.1002/art.22564

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