TOP3A

Topoisomerase (DNA) III alpha, also known as TOP3A, is a human gene.cite web | title = Entrez Gene: TOP3A topoisomerase (DNA) III alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7156| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.cite web | title = Entrez Gene: TOP3A topoisomerase (DNA) III alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7156| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hanai R, Caron PR, Wang JC |title=Human TOP3: a single-copy gene encoding DNA topoisomerase III. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3653–7 |year= 1996 |pmid= 8622991 |doi=
*cite journal | author=Fritz E, Elsea SH, Patel PI, Meyn MS |title=Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4538–42 |year= 1997 |pmid= 9114025 |doi=
*cite journal | author=Elsea SH, Fritz E, Schoener-Scott R, "et al." |title=Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity. |journal=Am. J. Med. Genet. |volume=75 |issue= 1 |pages= 104–8 |year= 1998 |pmid= 9450867 |doi=
*cite journal | author=Kim JC, Yoon JB, Koo HS, Chung IK |title=Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26130–7 |year= 1998 |pmid= 9748294 |doi=
*cite journal | author=Goulaouic H, Roulon T, Flamand O, "et al." |title=Purification and characterization of human DNA topoisomerase IIIalpha. |journal=Nucleic Acids Res. |volume=27 |issue= 12 |pages= 2443–50 |year= 1999 |pmid= 10352172 |doi=
*cite journal | author=Shimamoto A, Nishikawa K, Kitao S, Furuichi Y |title=Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. |journal=Nucleic Acids Res. |volume=28 |issue= 7 |pages= 1647–55 |year= 2000 |pmid= 10710432 |doi=
*cite journal | author=Wu L, Davies SL, North PS, "et al." |title=The Bloom's syndrome gene product interacts with topoisomerase III. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9636–44 |year= 2000 |pmid= 10734115 |doi=
*cite journal | author=Lin CW, Darzynkiewicz Z, Li X, "et al." |title=Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes. |journal=Exp. Cell Res. |volume=256 |issue= 1 |pages= 225–36 |year= 2000 |pmid= 10739669 |doi= 10.1006/excr.1999.4778
*cite journal | author=Brosh RM, Li JL, Kenny MK, "et al." |title=Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23500–8 |year= 2000 |pmid= 10825162 |doi= 10.1074/jbc.M001557200
*cite journal | author=Lodge AJ, Anderson JJ, Ng SW, "et al." |title=Expression of topoisomerase IIIalpha in normal and neoplastic tissues determined by immunohistochemistry using a novel monoclonal antibody. |journal=Br. J. Cancer |volume=83 |issue= 4 |pages= 498–505 |year= 2000 |pmid= 10945498 |doi= 10.1054/bjoc.2000.1293
*cite journal | author=Hu P, Beresten SF, van Brabant AJ, "et al." |title=Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. |journal=Hum. Mol. Genet. |volume=10 |issue= 12 |pages= 1287–98 |year= 2001 |pmid= 11406610 |doi=
*cite journal | author=Freire R, d'Adda Di Fagagna F, Wu L, "et al." |title=Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha. |journal=Nucleic Acids Res. |volume=29 |issue= 15 |pages= 3172–80 |year= 2001 |pmid= 11470874 |doi=
*cite journal | author=Bi W, Yan J, Stankiewicz P, "et al." |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702
*cite journal | author=Wang Y, Lyu YL, Wang JC |title=Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12114–9 |year= 2002 |pmid= 12209014 |doi= 10.1073/pnas.192449499
*cite journal | author=Wu L, Hickson ID |title=The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha. |journal=Nucleic Acids Res. |volume=30 |issue= 22 |pages= 4823–9 |year= 2002 |pmid= 12433984 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Meetei AR, de Winter JP, Medhurst AL, "et al." |title=A novel ubiquitin ligase is deficient in Fanconi anemia. |journal=Nat. Genet. |volume=35 |issue= 2 |pages= 165–70 |year= 2003 |pmid= 12973351 |doi= 10.1038/ng1241
*cite journal | author=Jiao R, Bachrati CZ, Pedrazzi G, "et al." |title=Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1. |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 4710–9 |year= 2004 |pmid= 15143166 |doi= 10.1128/MCB.24.11.4710-4719.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yin J, Sobeck A, Xu C, "et al." |title=BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. |journal=EMBO J. |volume=24 |issue= 7 |pages= 1465–76 |year= 2005 |pmid= 15775963 |doi= 10.1038/sj.emboj.7600622

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