ST8SIA1

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1, also known as ST8SIA1, is a human gene.cite web | title = Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6489| accessdate = ]

PBB_Summary
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summary_text = Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.cite web | title = Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6489| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sasaki K, Watanabe E, Kawashima K, "et al." |title=Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22782–7 |year= 1993 |pmid= 7901202 |doi=
*cite journal | author=Haraguchi M, Yamashiro S, Yamamoto A, "et al." |title=Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10455–9 |year= 1994 |pmid= 7937974 |doi=
*cite journal | author=Nara K, Watanabe Y, Maruyama K, "et al." |title=Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 17 |pages= 7952–6 |year= 1994 |pmid= 8058740 |doi=
*cite journal | author=Sasaki K, Kurata K, Kojima N, "et al." |title=Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). |journal=J. Biol. Chem. |volume=269 |issue= 22 |pages= 15950–6 |year= 1994 |pmid= 8195250 |doi=
*cite journal | author=Nakayama J, Fukuda MN, Hirabayashi Y, "et al." |title=Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3684–91 |year= 1996 |pmid= 8631981 |doi=
*cite journal | author=Matsuda Y, Nara K, Watanabe Y, "et al." |title=Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse. |journal=Genomics |volume=32 |issue= 1 |pages= 137–9 |year= 1996 |pmid= 8786103 |doi= 10.1006/geno.1996.0090
*cite journal | author=De Maria R, Lenti L, Malisan F, "et al." |title=Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. |journal=Science |volume=277 |issue= 5332 |pages= 1652–5 |year= 1997 |pmid= 9287216 |doi=
*cite journal | author=Angata K, Suzuki M, McAuliffe J, "et al." |title=Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18594–601 |year= 2000 |pmid= 10766765 |doi= 10.1074/jbc.M910204199
*cite journal | author=Zeng G, Gao L, Suetake K, "et al." |title=Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed. |journal=Cancer Lett. |volume=178 |issue= 1 |pages= 91–8 |year= 2002 |pmid= 11849746 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Furukawa K, Horie M, Okutomi K, "et al." |title=Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene. |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2-3 |pages= 71–8 |year= 2003 |pmid= 12818424 |doi=
*cite journal | author=Moon SK, Kim HM, Lee YC, Kim CH |title=Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33063–70 |year= 2004 |pmid= 15175338 |doi= 10.1074/jbc.M313462200
*cite journal | author=Ha KT, Lee YC, Kim CH |title=Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2. |journal=FEBS Lett. |volume=568 |issue= 1-3 |pages= 183–7 |year= 2004 |pmid= 15196944 |doi= 10.1016/j.febslet.2004.05.020
*cite journal | author=Tomassini B, Malisan F, Franchi L, "et al." |title=Calnexin suppresses GD3 synthase-induced apoptosis. |journal=FASEB J. |volume=18 |issue= 13 |pages= 1553–5 |year= 2005 |pmid= 15319364 |doi= 10.1096/fj.04-1675fje
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Teintenier-Lelièvre M, Julien S, Juliant S, "et al." |title=Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins. |journal=Biochem. J. |volume=392 |issue= Pt 3 |pages= 665–74 |year= 2006 |pmid= 16120058 |doi= 10.1042/BJ20051120
*cite journal | author=Kang NY, Kang Y, Kang SK, "et al." |title=Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression. |journal=Glycobiology |volume=16 |issue= 5 |pages= 375–89 |year= 2006 |pmid= 16481330 |doi= 10.1093/glycob/cwj087
*cite journal | author=Ko K, Furukawa K, Takahashi T, "et al." |title=Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers. |journal=Oncogene |volume=25 |issue= 52 |pages= 6924–35 |year= 2006 |pmid= 16862187 |doi= 10.1038/sj.onc.1209683

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