EXOC2

Exocyst complex component 2, also known as EXOC2, is a human gene.cite web | title = Entrez Gene: EXOC2 exocyst complex component 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55770| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.cite web | title = Entrez Gene: EXOC2 exocyst complex component 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55770| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis. |journal=Int. Rev. Cytol. |volume=233 |issue= |pages= 243–65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8
*cite journal | author=Kee Y, Yoo JS, Hazuka CD, "et al." |title=Subunit structure of the mammalian exocyst complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438–43 |year= 1998 |pmid= 9405631 |doi=
*cite journal | author=Hsu SC, Hazuka CD, Roth R, "et al." |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111–22 |year= 1998 |pmid= 9655500 |doi=
*cite journal | author=Matern HT, Yeaman C, Nelson WJ, Scheller RH |title=The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9648–53 |year= 2001 |pmid= 11493706 |doi= 10.1073/pnas.171317898
*cite journal | author=Sugihara K, Asano S, Tanaka K, "et al." |title=The exocyst complex binds the small GTPase RalA to mediate filopodia formation. |journal=Nat. Cell Biol. |volume=4 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11744922 |doi= 10.1038/ncb720
*cite journal | author=Sjölinder M, Uhlmann J, Ponstingl H |title=DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. |journal=FEBS Lett. |volume=532 |issue= 1-2 |pages= 211–5 |year= 2003 |pmid= 12459492 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Murthy M, Garza D, Scheller RH, Schwarz TL |title=Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. |journal=Neuron |volume=37 |issue= 3 |pages= 433–47 |year= 2003 |pmid= 12575951 |doi=
*cite journal | author=Mott HR, Nietlispach D, Hopkins LJ, "et al." |title=Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17053–9 |year= 2003 |pmid= 12624092 |doi= 10.1074/jbc.M300155200
*cite journal | author=Inoue M, Chang L, Hwang J, "et al." |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. |journal=Nature |volume=422 |issue= 6932 |pages= 629–33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533
*cite journal | author=Fukai S, Matern HT, Jagath JR, "et al." |title=Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. |journal=EMBO J. |volume=22 |issue= 13 |pages= 3267–78 |year= 2003 |pmid= 12839989 |doi= 10.1093/emboj/cdg329
*cite journal | author=Moskalenko S, Tong C, Rosse C, "et al." |title=Ral GTPases regulate exocyst assembly through dual subunit interactions. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743–8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jin R, Junutula JR, Matern HT, "et al." |title=Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. |journal=EMBO J. |volume=24 |issue= 12 |pages= 2064–74 |year= 2005 |pmid= 15920473 |doi= 10.1038/sj.emboj.7600699
*cite journal | author=Chien Y, Kim S, Bumeister R, "et al." |title=RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. |journal=Cell |volume=127 |issue= 1 |pages= 157–70 |year= 2006 |pmid= 17018283 |doi= 10.1016/j.cell.2006.08.034
*cite journal | author=Sulem P, Gudbjartsson DF, Stacey SN, "et al." |title=Genetic determinants of hair, eye and skin pigmentation in Europeans. |journal=Nat. Genet. |volume=39 |issue= 12 |pages= 1443–52 |year= 2007 |pmid= 17952075 |doi= 10.1038/ng.2007.13

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