PIGT

Phosphatidylinositol glycan anchor biosynthesis, class T, also known as PIGT, is a human gene.cite web | title = Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51604| accessdate = ] cite journal | author = Ohishi K, Inoue N, Kinoshita T | title = PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4088–98 | year = 2001 | month = August | pmid = 11483512 | pmc = 149153 | doi = 10.1093/emboj/20.15.4088 | url = | issn = ]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.

Trivia

The PIGT gene was referenced in a sketch on the TV show Armstrong and Miller due to the habit of predictive text messaging phones to guess the relatively obscure 'PIGT' when the keys 7448 are pressed, instead of a common swear word.cite web | url = http://www(dot)5min(dot)com/Video/How-to-Use-Predictive-Text-Swearing-7208501 | title = How to Use Predictive Text Swearing video and other Life 101 videos at 5min | author = | authorlink = | coauthors = | date = | format = | work = | publisher = 5min Life Videopedia | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-09-02]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Eisenhaber B, Maurer-Stroh S, Novatchkova M, "et al." |title=Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. |journal=Bioessays |volume=25 |issue= 4 |pages= 367–85 |year= 2003 |pmid= 12655644 |doi= 10.1002/bies.10254
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Lai CH, Chou CY, Ch'ang LY, "et al." |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=
*cite journal | author=Ohishi K, Inoue N, Kinoshita T |title=PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4088–98 |year= 2001 |pmid= 11483512 |doi= 10.1093/emboj/20.15.4088
*cite journal | author=Yu Y, Zhang C, Zhou G, "et al." |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501
*cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, "et al." |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Vainauskas S, Maeda Y, Kurniawan H, "et al." |title=Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30535–42 |year= 2002 |pmid= 12052837 |doi= 10.1074/jbc.M205402200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ohishi K, Nagamune K, Maeda Y, Kinoshita T |title=Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13959–67 |year= 2003 |pmid= 12582175 |doi= 10.1074/jbc.M300586200
*cite journal | author=Hong Y, Ohishi K, Kang JY, "et al." |title=Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. |journal=Mol. Biol. Cell |volume=14 |issue= 5 |pages= 1780–9 |year= 2004 |pmid= 12802054 |doi= 10.1091/mbc.E02-12-0794
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vainauskas S, Menon AK |title=Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 16402–9 |year= 2005 |pmid= 15713669 |doi= 10.1074/jbc.M414253200
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Li HL, Li Z, Qin LY, "et al." |title=The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. |journal=FEBS Lett. |volume=580 |issue= 7 |pages= 1723–8 |year= 2006 |pmid= 16516892 |doi= 10.1016/j.febslet.2006.02.022

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