EIF2C1

Eukaryotic translation initiation factor 2C, 1, also known as EIF2C1, is a human gene.cite web | title = Entrez Gene: EIF2C1 eukaryotic translation initiation factor 2C, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26523| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.cite web | title = Entrez Gene: EIF2C1 eukaryotic translation initiation factor 2C, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26523| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Carmell MA, Xuan Z, Zhang MQ, Hannon GJ |title=The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. |journal=Genes Dev. |volume=16 |issue= 21 |pages= 2733–42 |year= 2002 |pmid= 12414724 |doi= 10.1101/gad.1026102
*cite journal | author=Reddy PH, Stockburger E, Gillevet P, Tagle DA |title=Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. |journal=Genomics |volume=46 |issue= 2 |pages= 174–82 |year= 1998 |pmid= 9417904 |doi= 10.1006/geno.1997.5044
*cite journal | author=Cikaluk DE, Tahbaz N, Hendricks LC, "et al." |title=GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation. |journal=Mol. Biol. Cell |volume=10 |issue= 10 |pages= 3357–72 |year= 1999 |pmid= 10512872 |doi=
*cite journal | author=Koesters R, Adams V, Betts D, "et al." |title=Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. |journal=Genomics |volume=61 |issue= 2 |pages= 210–8 |year= 1999 |pmid= 10534406 |doi= 10.1006/geno.1999.5951
*cite journal | author=Martinez J, Patkaniowska A, Urlaub H, "et al." |title=Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. |journal=Cell |volume=110 |issue= 5 |pages= 563–74 |year= 2003 |pmid= 12230974 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Doi N, Zenno S, Ueda R, "et al." |title=Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. |journal=Curr. Biol. |volume=13 |issue= 1 |pages= 41–6 |year= 2003 |pmid= 12526743 |doi=
*cite journal | author=Sasaki T, Shiohama A, Minoshima S, Shimizu N |title=Identification of eight members of the Argonaute family in the human genome small star, filled. |journal=Genomics |volume=82 |issue= 3 |pages= 323–30 |year= 2004 |pmid= 12906857 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ma JB, Ye K, Patel DJ |title=Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. |journal=Nature |volume=429 |issue= 6989 |pages= 318–22 |year= 2004 |pmid= 15152257 |doi= 10.1038/nature02519
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Sen GL, Blau HM |title=Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 6 |pages= 633–6 |year= 2005 |pmid= 15908945 |doi= 10.1038/ncb1265
*cite journal | author=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719–23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Chu CY, Rana TM |title=Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. |journal=PLoS Biol. |volume=4 |issue= 7 |pages= e210 |year= 2006 |pmid= 16756390 |doi= 10.1371/journal.pbio.0040210
*cite journal | author=Kim DH, Villeneuve LM, Morris KV, Rossi JJ |title=Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 9 |pages= 793–7 |year= 2006 |pmid= 16936726 |doi= 10.1038/nsmb1142
*cite journal | author=Janowski BA, Huffman KE, Schwartz JC, "et al." |title=Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 9 |pages= 787–92 |year= 2006 |pmid= 16936728 |doi= 10.1038/nsmb1140
*cite journal | author=Sasaki T, Shimizu N |title=Evolutionary conservation of a unique amino acid sequence in human DICER protein essential for binding to Argonaute family proteins. |journal=Gene |volume=396 |issue= 2 |pages= 312–20 |year= 2007 |pmid= 17482383 |doi= 10.1016/j.gene.2007.04.001

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes