GAPDHS

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, also known as GAPDHS, is a human gene.cite web | title = Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26330| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.cite web | title = Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26330| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cooper TG, Yeung CH |title=Approaches to post-testicular contraception. |journal=Asian J. Androl. |volume=1 |issue= 1-2 |pages= 29–36 |year= 2001 |pmid= 11225901 |doi=
*cite journal | author=Benham FJ, Povey S |title=Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations. |journal=Genomics |volume=5 |issue= 2 |pages= 209–14 |year= 1989 |pmid= 2793178 |doi=
*cite journal | author=Peterson RN, Freund M |title=Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa. |journal=Biol. Reprod. |volume=8 |issue= 3 |pages= 350–7 |year= 1973 |pmid= 4349855 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Westhoff D, Kamp G |title=Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa. |journal=J. Cell. Sci. |volume=110 ( Pt 15) |issue= |pages= 1821–9 |year= 1997 |pmid= 9264469 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S |title=L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa. |journal=Mol. Hum. Reprod. |volume=6 |issue= 2 |pages= 127–36 |year= 2000 |pmid= 10655454 |doi=
*cite journal | author=Welch JE, Brown PL, O'Brien DA, "et al." |title=Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. |journal=J. Androl. |volume=21 |issue= 2 |pages= 328–38 |year= 2000 |pmid= 10714828 |doi=
*cite journal | author=Bone W, Jones AR, Morin C, "et al." |title=Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. |journal=J. Androl. |volume=22 |issue= 3 |pages= 464–70 |year= 2001 |pmid= 11330647 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li Y, Nowotny P, Holmans P, "et al." |title=Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15688–93 |year= 2004 |pmid= 15507493 |doi= 10.1073/pnas.0403535101
*cite journal | author=Kodama R, Kondo T, Yokote H, "et al." |title=Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+). |journal=Genes Cells |volume=10 |issue= 12 |pages= 1211–9 |year= 2006 |pmid= 16324157 |doi= 10.1111/j.1365-2443.2005.00911.x
*cite journal | author=Welch JE, Barbee RR, Magyar PL, "et al." |title=Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. |journal=Mol. Reprod. Dev. |volume=73 |issue= 8 |pages= 1052–60 |year= 2007 |pmid= 16700075 |doi= 10.1002/mrd.20235
*cite journal | author=Yatsenko AN, Roy A, Chen R, "et al." |title=Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. |journal=Hum. Mol. Genet. |volume=15 |issue= 23 |pages= 3411–9 |year= 2007 |pmid= 17047026 |doi= 10.1093/hmg/ddl417
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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