Flightless I homolog (Drosophila), also known as FLII, is a human gene.cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = ]

section_title =
summary_text = This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = ]


Further reading

citations =
*cite journal | author=Chen KS, Gunaratne PH, Hoheisel JD, "et al." |title=The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2. |journal=Am. J. Hum. Genet. |volume=56 |issue= 1 |pages= 175–82 |year= 1995 |pmid= 7825574 |doi=
*cite journal | author=Campbell HD, Schimansky T, Claudianos C, "et al." |title=The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11386–90 |year= 1994 |pmid= 8248259 |doi=
*cite journal | author=Campbell HD, Fountain S, Young IG, "et al." |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46–54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709
*cite journal | author=Liu YT, Yin HL |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7920–7 |year= 1998 |pmid= 9525888 |doi=
*cite journal | author=Wilson SA, Brown EC, Kingsman AJ, Kingsman SM |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3460–7 |year= 1998 |pmid= 9671805 |doi=
*cite journal | author=Fong KS, de Couet HG |title=Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. |journal=Genomics |volume=58 |issue= 2 |pages= 146–57 |year= 1999 |pmid= 10366446 |doi= 10.1006/geno.1999.5817
*cite journal | author=Davy DA, Campbell HD, Fountain S, "et al." |title=The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. |journal=J. Cell. Sci. |volume=114 |issue= Pt 3 |pages= 549–62 |year= 2001 |pmid= 11171324 |doi=
*cite journal | author=Campbell HD, Fountain S, McLennan IS, "et al." |title=Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3518–26 |year= 2002 |pmid= 11971982 |doi=
*cite journal | author=Bi W, Yan J, Stankiewicz P, "et al." |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Lee YH, Campbell HD, Stallcup MR |title=Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 2103–17 |year= 2004 |pmid= 14966289 |doi=
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wang T, Chuang TH, Ronni T, "et al." |title=Flightless I homolog negatively modulates the TLR pathway. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1355–62 |year= 2006 |pmid= 16424162 |doi=
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Kinsey M, Smith R, Lessnick SL |title=NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. |journal=Mol. Cancer Res. |volume=4 |issue= 11 |pages= 851–9 |year= 2007 |pmid= 17114343 |doi= 10.1158/1541-7786.MCR-06-0090

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