TMED10

Transmembrane emp24-like trafficking protein 10 (yeast), also known as TMED10, is a human gene.cite web | title = Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10972| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.cite web | title = Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10972| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sherrington R, Rogaev EI, Liang Y, "et al." |title=Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. |journal=Nature |volume=375 |issue= 6534 |pages= 754–60 |year= 1995 |pmid= 7596406 |doi= 10.1038/375754a0
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Blum R, Feick P, Puype M, "et al." |title=Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17183–9 |year= 1996 |pmid= 8663407 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Gommel D, Orci L, Emig EM, "et al." |title=p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. |journal=FEBS Lett. |volume=447 |issue= 2-3 |pages= 179–85 |year= 1999 |pmid= 10214941 |doi=
*cite journal | author=Hörer J, Blum R, Feick P, "et al." |title=A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II. |journal=DNA Seq. |volume=10 |issue= 2 |pages= 121–6 |year= 1999 |pmid= 10376215 |doi=
*cite journal | author=Wang H, Kazanietz MG |title=Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4541–50 |year= 2002 |pmid= 11689559 |doi= 10.1074/jbc.M107150200
*cite journal | author=Majoul I, Straub M, Hell SW, "et al." |title=KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. |journal=Dev. Cell |volume=1 |issue= 1 |pages= 139–53 |year= 2001 |pmid= 11703931 |doi=
*cite journal | author=Gommel DU, Memon AR, Heiss A, "et al." |title=Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. |journal=EMBO J. |volume=20 |issue= 23 |pages= 6751–60 |year= 2002 |pmid= 11726511 |doi= 10.1093/emboj/20.23.6751
*cite journal | author=Barr FA, Preisinger C, Kopajtich R, Körner R |title=Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 885–91 |year= 2002 |pmid= 11739402 |doi= 10.1083/jcb.200108102
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Heilig R, Eckenberg R, Petit JL, "et al." |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Breuza L, Halbeisen R, Jenö P, "et al." |title=Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47242–53 |year= 2004 |pmid= 15308636 |doi= 10.1074/jbc.M406644200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chen F, Hasegawa H, Schmitt-Ulms G, "et al." |title=TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. |journal=Nature |volume=440 |issue= 7088 |pages= 1208–12 |year= 2006 |pmid= 16641999 |doi= 10.1038/nature04667
*cite journal | author=Chi A, Valencia JC, Hu ZZ, "et al." |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j

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