ENOX2

Cytosolic ovarian carcinoma antigen 1, also known as COVA1, is a human gene.cite web | title = Entrez Gene: COVA1 cytosolic ovarian carcinoma antigen 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10495| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: COVA1 cytosolic ovarian carcinoma antigen 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10495| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tarasoutchi F, Grinberg M, de Figueiredo Neto JA, "et al." |title= [Mitral valve aneurysm associated with mitral insufficiency in absence of aortic insufficiency] |journal=Arq. Bras. Cardiol. |volume=56 |issue= 3 |pages= 231–4 |year= 1991 |pmid= 1888291 |doi=
*cite journal | author=Chang K, Pastan I |title=Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line. |journal=Int. J. Cancer |volume=57 |issue= 1 |pages= 90–7 |year= 1994 |pmid= 8150545 |doi=
*cite journal | author=Dai S, Morré DJ, Geilen CC, "et al." |title=Inhibition of plasma membrane NADH oxidase activity and growth of HeLa cells by natural and synthetic retinoids. |journal=Mol. Cell. Biochem. |volume=166 |issue= 1-2 |pages= 101–9 |year= 1997 |pmid= 9046026 |doi=
*cite journal | author=Morré DJ, Chueh PJ, Lawler J, Morré DM |title=The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity. |journal=J. Bioenerg. Biomembr. |volume=30 |issue= 5 |pages= 477–87 |year= 1999 |pmid= 9932650 |doi=
*cite journal | author=Kishi T, Morré DM, Morré DJ |title=The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity. |journal=Biochim. Biophys. Acta |volume=1412 |issue= 1 |pages= 66–77 |year= 1999 |pmid= 10354495 |doi=
*cite journal | author=Kelker M, Kim C, Chueh PJ, "et al." |title=Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion. |journal=Biochemistry |volume=40 |issue= 25 |pages= 7351–4 |year= 2001 |pmid= 11412089 |doi=
*cite journal | author=Yantiri F, Morré DJ |title=Isolation and characterization of a tumor-associated NADH oxidase (tNOX) from the HeLa cell surface. |journal=Arch. Biochem. Biophys. |volume=391 |issue= 2 |pages= 149–59 |year= 2001 |pmid= 11437345 |doi= 10.1006/abbi.2001.2404
*cite journal | author=Morré DJ, Sedlak D, Tang X, "et al." |title=Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs. |journal=Arch. Biochem. Biophys. |volume=392 |issue= 2 |pages= 251–6 |year= 2001 |pmid= 11488599 |doi= 10.1006/abbi.2001.2436
*cite journal | author=Chueh PJ, Morré DM, Morré DJ |title=A site-directed mutagenesis analysis of tNOX functional domains. |journal=Biochim. Biophys. Acta |volume=1594 |issue= 1 |pages= 74–83 |year= 2002 |pmid= 11825610 |doi=
*cite journal | author=Chueh PJ, Kim C, Cho N, "et al." |title=Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. |journal=Biochemistry |volume=41 |issue= 11 |pages= 3732–41 |year= 2002 |pmid= 11888291 |doi=
*cite journal | author=Cho N, Chueh PJ, Kim C, "et al." |title=Monoclonal antibody to a cancer-specific and drug-responsive hydroquinone (NADH) oxidase from the sera of cancer patients. |journal=Cancer Immunol. Immunother. |volume=51 |issue= 3 |pages= 121–9 |year= 2002 |pmid= 11941450 |doi= 10.1007/s00262-001-0262-2
*cite journal | author=Morré DJ, Chueh PJ, Pletcher J, "et al." |title=Biochemical basis for the biological clock. |journal=Biochemistry |volume=41 |issue= 40 |pages= 11941–5 |year= 2002 |pmid= 12356293 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chueh PJ, Wu LY, Morré DM, Morré DJ |title=tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate. |journal=Biofactors |volume=20 |issue= 4 |pages= 235–49 |year= 2005 |pmid= 15706060 |doi=
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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