SYVN1

Synovial apoptosis inhibitor 1, synoviolin, also known as SYVN1, is a human gene.cite web | title = Entrez Gene: SYVN1 synovial apoptosis inhibitor 1, synoviolin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84447| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence. Sequence analysis identified two transcript variants that encode different isoforms.cite web | title = Entrez Gene: SYVN1 synovial apoptosis inhibitor 1, synoviolin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84447| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Nagase T, Nakayama M, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=
*cite journal | author=Kaneko M, Ishiguro M, Niinuma Y, "et al." |title=Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. |journal=FEBS Lett. |volume=532 |issue= 1-2 |pages= 147–52 |year= 2003 |pmid= 12459480 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nadav E, Shmueli A, Barr H, "et al." |title=A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 91–7 |year= 2003 |pmid= 12646171 |doi=
*cite journal | author=Amano T, Yamasaki S, Yagishita N, "et al." |title=Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. |journal=Genes Dev. |volume=17 |issue= 19 |pages= 2436–49 |year= 2003 |pmid= 12975321 |doi= 10.1101/gad.1096603
*cite journal | author=Kikkert M, Doolman R, Dai M, "et al." |title=Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3525–34 |year= 2004 |pmid= 14593114 |doi= 10.1074/jbc.M307453200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lilley BN, Ploegh HL |title=Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 40 |pages= 14296–301 |year= 2006 |pmid= 16186509 |doi= 10.1073/pnas.0505014102
*cite journal | author=Ye Y, Shibata Y, Kikkert M, "et al." |title=Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 40 |pages= 14132–8 |year= 2006 |pmid= 16186510 |doi= 10.1073/pnas.0505006102
*cite journal | author=Schulze A, Standera S, Buerger E, "et al." |title=The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. |journal=J. Mol. Biol. |volume=354 |issue= 5 |pages= 1021–7 |year= 2006 |pmid= 16289116 |doi= 10.1016/j.jmb.2005.10.020
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Yamasaki S, Yagishita N, Tsuchimochi K, "et al." |title=Resistance to endoplasmic reticulum stress is an acquired cellular characteristic of rheumatoid synovial cells. |journal=Int. J. Mol. Med. |volume=18 |issue= 1 |pages= 113–7 |year= 2006 |pmid= 16786162 |doi=
*cite journal | author=Toh ML, Marotte H, Blond JL, "et al." |title=Overexpression of synoviolin in peripheral blood and synoviocytes from rheumatoid arthritis patients and continued elevation in nonresponders to infliximab treatment. |journal=Arthritis Rheum. |volume=54 |issue= 7 |pages= 2109–18 |year= 2006 |pmid= 16802346 |doi= 10.1002/art.21926
*cite journal | author=Arteaga MF, Wang L, Ravid T, "et al." |title=An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 30 |pages= 11178–83 |year= 2006 |pmid= 16847254 |doi= 10.1073/pnas.0604816103
*cite journal | author=Omura T, Kaneko M, Okuma Y, "et al." |title=A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. |journal=J. Neurochem. |volume=99 |issue= 6 |pages= 1456–69 |year= 2007 |pmid= 17059562 |doi= 10.1111/j.1471-4159.2006.04155.x
*cite journal | author=Yang H, Zhong X, Ballar P, "et al." |title=Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. |journal=Exp. Cell Res. |volume=313 |issue= 3 |pages= 538–50 |year= 2007 |pmid= 17141218 |doi= 10.1016/j.yexcr.2006.10.031
*cite journal | author=Yamasaki S, Yagishita N, Sasaki T, "et al." |title=Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. |journal=EMBO J. |volume=26 |issue= 1 |pages= 113–22 |year= 2007 |pmid= 17170702 |doi= 10.1038/sj.emboj.7601490

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