BLMH

Bleomycin hydrolase, also known as BLMH, is a human gene.cite web | title = Entrez Gene: BLMH bleomycin hydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=642| accessdate = ]

PBB_Summary
section_title =
summary_text = Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.cite web | title = Entrez Gene: BLMH bleomycin hydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=642| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Ferrando AA, Velasco G, Campo E, Lopez-Otin C |title=Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. |journal=Cancer Res. |volume=56 |issue= 8 |pages= 1746–50 |year= 1996 |pmid= 8620487 |doi=
*cite journal | author=Brömme D, Rossi AB, Smeekens SP, "et al." |title=Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. |journal=Biochemistry |volume=35 |issue= 21 |pages= 6706–14 |year= 1996 |pmid= 8639621 |doi= 10.1021/bi960092y
*cite journal | author=Montoya SE, Ferrell RE, Lazo JS |title=Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase. |journal=Cancer Res. |volume=57 |issue= 19 |pages= 4191–5 |year= 1997 |pmid= 9331073 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ferrando AA, Pendás AM, Llano E, "et al." |title=Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33298–304 |year= 1998 |pmid= 9407121 |doi=
*cite journal | author=Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS |title=Essential binding and functional domains of human bleomycin hydrolase. |journal=Biochemistry |volume=37 |issue= 8 |pages= 2282–90 |year= 1998 |pmid= 9485374 |doi= 10.1021/bi9722204
*cite journal | author=Montoya SE, Aston CE, DeKosky ST, "et al." |title=Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 211–2 |year= 1998 |pmid= 9500538 |doi= 10.1038/ng0398-211
*cite journal | author=Zheng W, Johnston SA, Joshua-Tor L |title=The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. |journal=Cell |volume=93 |issue= 1 |pages= 103–9 |year= 1998 |pmid= 9546396 |doi=
*cite journal | author=Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS |title=An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9. |journal=Mol. Pharmacol. |volume=54 |issue= 6 |pages= 954–61 |year= 1999 |pmid= 9855622 |doi=
*cite journal | author=Takeda A, Nonaka M, Ishikawa A, Higuchi D |title=Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin. |journal=Arch. Dermatol. Res. |volume=291 |issue= 4 |pages= 238–40 |year= 1999 |pmid= 10335922 |doi=
*cite journal | author=Koldamova RP, Lefterov IM, DiSabella MT, "et al." |title=Human bleomycin hydrolase binds ribosomal proteins. |journal=Biochemistry |volume=38 |issue= 22 |pages= 7111–7 |year= 1999 |pmid= 10353821 |doi= 10.1021/bi990135l
*cite journal | author=O'Farrell PA, Gonzalez F, Zheng W, "et al." |title=Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. |journal=Structure |volume=7 |issue= 6 |pages= 619–27 |year= 1999 |pmid= 10404591 |doi=
*cite journal | author=Malherbe P, Faull RL, Richards JG |title=Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains. |journal=Neurosci. Lett. |volume=281 |issue= 1 |pages= 37–40 |year= 2000 |pmid= 10686410 |doi=
*cite journal | author=Lefterov IM, Koldamova RP, Lazo JS |title=Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. |journal=FASEB J. |volume=14 |issue= 12 |pages= 1837–47 |year= 2000 |pmid= 10973933 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nivet-Antoine V, Coulhon MP, Le Denmat C, "et al." |title= [Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases] |journal=Ann. Biol. Clin. (Paris) |volume=61 |issue= 1 |pages= 61–7 |year= 2003 |pmid= 12604387 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes