- SELS (gene)
Selenoprotein S, also known as SELS, is a human
gene .cite web | title = Entrez Gene: SELS selenoprotein S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55829| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: SELS selenoprotein S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55829| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Walder K, Kantham L, McMillan JS, "et al." |title=Tanis: a link between type 2 diabetes and inflammation? |journal=Diabetes |volume=51 |issue= 6 |pages= 1859–66 |year= 2002 |pmid= 12031974 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gao Y, Walder K, Sunderland T, "et al." |title=Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells. |journal=Diabetes |volume=52 |issue= 4 |pages= 929–34 |year= 2003 |pmid= 12663463 |doi=
*cite journal | author=Kryukov GV, Castellano S, Novoselov SV, "et al." |title=Characterization of mammalian selenoproteomes. |journal=Science |volume=300 |issue= 5624 |pages= 1439–43 |year= 2003 |pmid= 12775843 |doi= 10.1126/science.1083516
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gao Y, Feng HC, Walder K, "et al." |title=Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein. |journal=FEBS Lett. |volume=563 |issue= 1-3 |pages= 185–90 |year= 2004 |pmid= 15063746 |doi= 10.1016/S0014-5793(04)00296-0
*cite journal | author=Karlsson HK, Tsuchida H, Lake S, "et al." |title=Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects. |journal=Diabetes |volume=53 |issue= 6 |pages= 1424–8 |year= 2004 |pmid= 15161744 |doi=
*cite journal | author=Ye Y, Shibata Y, Yun C, "et al." |title=A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. |journal=Nature |volume=429 |issue= 6994 |pages= 841–7 |year= 2004 |pmid= 15215856 |doi= 10.1038/nature02656
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lilley BN, Ploegh HL |title=Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 40 |pages= 14296–301 |year= 2006 |pmid= 16186509 |doi= 10.1073/pnas.0505014102
*cite journal | author=Ye Y, Shibata Y, Kikkert M, "et al." |title=Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 40 |pages= 14132–8 |year= 2006 |pmid= 16186510 |doi= 10.1073/pnas.0505006102
*cite journal | author=Curran JE, Jowett JB, Elliott KS, "et al." |title=Genetic variation in selenoprotein S influences inflammatory response. |journal=Nat. Genet. |volume=37 |issue= 11 |pages= 1234–41 |year= 2006 |pmid= 16227999 |doi= 10.1038/ng1655
*cite journal | author=Gao Y, Hannan NR, Wanyonyi S, "et al." |title=Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. |journal=Cytokine |volume=33 |issue= 5 |pages= 246–51 |year= 2006 |pmid= 16574427 |doi= 10.1016/j.cyto.2006.02.005
*cite journal | author=Gao Y, Pagnon J, Feng HC, "et al." |title=Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells. |journal=Biochem. Biophys. Res. Commun. |volume=356 |issue= 3 |pages= 636–41 |year= 2007 |pmid= 17374524 |doi= 10.1016/j.bbrc.2007.03.018
*cite journal | author=Seiderer J, Dambacher J, Kühnlein B, "et al." |title=The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation. |journal=Tissue Antigens |volume=70 |issue= 3 |pages= 238–46 |year= 2007 |pmid= 17661913 |doi= 10.1111/j.1399-0039.2007.00888.xPBB_Controls
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