AAK1

AP2 associated kinase 1, also known as AAK1, is a human gene.cite web | title = Entrez Gene: AAK1 AP2 associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848| accessdate = ]

PBB_Summary
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summary_text = Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.cite web | title = Entrez Gene: AAK1 AP2 associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Manning G, Whyte DB, Martinez R, "et al." |title=The protein kinase complement of the human genome. |journal=Science |volume=298 |issue= 5600 |pages= 1912–34 |year= 2003 |pmid= 12471243 |doi= 10.1126/science.1075762
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Ricotta D, Conner SD, Schmid SL, "et al." |title=Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. |journal=J. Cell Biol. |volume=156 |issue= 5 |pages= 791–5 |year= 2002 |pmid= 11877457 |doi= 10.1083/jcb.200111068
*cite journal | author=Conner SD, Schmid SL |title=Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. |journal=J. Cell Biol. |volume=156 |issue= 5 |pages= 921–9 |year= 2002 |pmid= 11877461 |doi= 10.1083/jcb.200108123
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Conner SD, Schmid SL |title=Differential requirements for AP-2 in clathrin-mediated endocytosis. |journal=J. Cell Biol. |volume=162 |issue= 5 |pages= 773–9 |year= 2003 |pmid= 12952931 |doi= 10.1083/jcb.200304069
*cite journal | author=Conner SD, Schröter T, Schmid SL |title=AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. |journal=Traffic |volume=4 |issue= 12 |pages= 885–90 |year= 2004 |pmid= 14617351 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mishra SK, Hawryluk MJ, Brett TJ, "et al." |title=Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 46191–203 |year= 2004 |pmid= 15292237 |doi= 10.1074/jbc.M408095200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Collawn JF |title=Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key. |journal=Am. J. Respir. Cell Mol. Biol. |volume=35 |issue= 1 |pages= 1–2 |year= 2006 |pmid= 16782842 |doi= 10.1165/rcmb.f317
*cite journal | author=Schmid EM, Ford MG, Burtey A, "et al." |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Takahashi T, Furuchi T, Naganuma A |title=Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11932–7 |year= 2007 |pmid= 17178891 |doi= 10.1158/0008-5472.CAN-06-3220
*cite journal | author=Henderson DM, Conner SD |title=A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. |journal=Mol. Biol. Cell |volume=18 |issue= 7 |pages= 2698–706 |year= 2007 |pmid= 17494869 |doi= 10.1091/mbc.E06-09-0831

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