LRAT

LRAT

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), also known as LRAT, is a human gene.cite web | title = Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9227| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.cite web | title = Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9227| accessdate = ]

ee also

* The Visual Cycle

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ross AC, Zolfaghari R |title=Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. |journal=J. Nutr. |volume=134 |issue= 1 |pages= 269S–275S |year= 2004 |pmid= 14704332 |doi=
*cite journal | author=Herr FM, Ong DE |title=Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. |journal=Biochemistry |volume=31 |issue= 29 |pages= 6748–55 |year= 1992 |pmid= 1322170 |doi=
*cite journal | author=Mata NL, Tsin AT |title=Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes. |journal=Biochim. Biophys. Acta |volume=1394 |issue= 1 |pages= 16–22 |year= 1998 |pmid= 9767084 |doi=
*cite journal | author=Ruiz A, Winston A, Lim YH, "et al." |title=Molecular and biochemical characterization of lecithin retinol acyltransferase. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3834–41 |year= 1999 |pmid= 9920938 |doi=
*cite journal | author=Mondal MS, Ruiz A, Bok D, Rando RR |title=Lecithin retinol acyltransferase contains cysteine residues essential for catalysis. |journal=Biochemistry |volume=39 |issue= 17 |pages= 5215–20 |year= 2000 |pmid= 10819989 |doi=
*cite journal | author=Ruiz A, Kuehn MH, Andorf JL, "et al." |title=Genomic organization and mutation analysis of the gene encoding lecithin retinol acyltransferase in human retinal pigment epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 1 |pages= 31–7 |year= 2001 |pmid= 11133845 |doi=
*cite journal | author=Andreola F, Giandomenico V, Spero R, De Luca LM |title=Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 920–4 |year= 2001 |pmid= 11162450 |doi= 10.1006/bbrc.2000.3995
*cite journal | author=Thompson DA, Li Y, McHenry CL, "et al." |title=Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 123–4 |year= 2001 |pmid= 11381255 |doi= 10.1038/88828
*cite journal | author=Jahng WJ, Cheung E, Rando RR |title=Lecithin retinol acyltransferase forms functional homodimers. |journal=Biochemistry |volume=41 |issue= 20 |pages= 6311–9 |year= 2002 |pmid= 12009892 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhan HC, Gudas LJ, Bok D, "et al." |title=Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. |journal=Clin. Cancer Res. |volume=9 |issue= 13 |pages= 4897–905 |year= 2004 |pmid= 14581364 |doi=
*cite journal | author=Jahng WJ, Xue L, Rando RR |title=Lecithin retinol acyltransferase is a founder member of a novel family of enzymes. |journal=Biochemistry |volume=42 |issue= 44 |pages= 12805–12 |year= 2004 |pmid= 14596594 |doi= 10.1021/bi035370p
*cite journal | author=Boorjian S, Tickoo SK, Mongan NP, "et al." |title=Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 10 |pages= 3429–37 |year= 2004 |pmid= 15161698 |doi= 10.1158/1078-0432.CCR-03-0756
*cite journal | author=Zolfaghari R, Ross AC |title=Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver. |journal=Gene |volume=341 |issue= |pages= 181–8 |year= 2005 |pmid= 15474300 |doi= 10.1016/j.gene.2004.06.043
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=O'Byrne SM, Wongsiriroj N, Libien J, "et al." |title=Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35647–57 |year= 2005 |pmid= 16115871 |doi= 10.1074/jbc.M507924200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Xue L, Jahng WJ, Gollapalli D, Rando RR |title=Palmitoyl transferase activity of lecithin retinol acyl transferase. |journal=Biochemistry |volume=45 |issue= 35 |pages= 10710–8 |year= 2006 |pmid= 16939223 |doi= 10.1021/bi060897y
*cite journal | author=Sénéchal A, Humbert G, Surget MO, "et al." |title=Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis. |journal=Am. J. Ophthalmol. |volume=142 |issue= 4 |pages= 702–4 |year= 2006 |pmid= 17011878 |doi= 10.1016/j.ajo.2006.04.057

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