LRAT

LRAT

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), also known as LRAT, is a human gene.cite web | title = Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9227| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.cite web | title = Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9227| accessdate = ]

ee also

* The Visual Cycle

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ross AC, Zolfaghari R |title=Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. |journal=J. Nutr. |volume=134 |issue= 1 |pages= 269S–275S |year= 2004 |pmid= 14704332 |doi=
*cite journal | author=Herr FM, Ong DE |title=Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. |journal=Biochemistry |volume=31 |issue= 29 |pages= 6748–55 |year= 1992 |pmid= 1322170 |doi=
*cite journal | author=Mata NL, Tsin AT |title=Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes. |journal=Biochim. Biophys. Acta |volume=1394 |issue= 1 |pages= 16–22 |year= 1998 |pmid= 9767084 |doi=
*cite journal | author=Ruiz A, Winston A, Lim YH, "et al." |title=Molecular and biochemical characterization of lecithin retinol acyltransferase. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3834–41 |year= 1999 |pmid= 9920938 |doi=
*cite journal | author=Mondal MS, Ruiz A, Bok D, Rando RR |title=Lecithin retinol acyltransferase contains cysteine residues essential for catalysis. |journal=Biochemistry |volume=39 |issue= 17 |pages= 5215–20 |year= 2000 |pmid= 10819989 |doi=
*cite journal | author=Ruiz A, Kuehn MH, Andorf JL, "et al." |title=Genomic organization and mutation analysis of the gene encoding lecithin retinol acyltransferase in human retinal pigment epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 1 |pages= 31–7 |year= 2001 |pmid= 11133845 |doi=
*cite journal | author=Andreola F, Giandomenico V, Spero R, De Luca LM |title=Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 920–4 |year= 2001 |pmid= 11162450 |doi= 10.1006/bbrc.2000.3995
*cite journal | author=Thompson DA, Li Y, McHenry CL, "et al." |title=Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 123–4 |year= 2001 |pmid= 11381255 |doi= 10.1038/88828
*cite journal | author=Jahng WJ, Cheung E, Rando RR |title=Lecithin retinol acyltransferase forms functional homodimers. |journal=Biochemistry |volume=41 |issue= 20 |pages= 6311–9 |year= 2002 |pmid= 12009892 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhan HC, Gudas LJ, Bok D, "et al." |title=Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. |journal=Clin. Cancer Res. |volume=9 |issue= 13 |pages= 4897–905 |year= 2004 |pmid= 14581364 |doi=
*cite journal | author=Jahng WJ, Xue L, Rando RR |title=Lecithin retinol acyltransferase is a founder member of a novel family of enzymes. |journal=Biochemistry |volume=42 |issue= 44 |pages= 12805–12 |year= 2004 |pmid= 14596594 |doi= 10.1021/bi035370p
*cite journal | author=Boorjian S, Tickoo SK, Mongan NP, "et al." |title=Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 10 |pages= 3429–37 |year= 2004 |pmid= 15161698 |doi= 10.1158/1078-0432.CCR-03-0756
*cite journal | author=Zolfaghari R, Ross AC |title=Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver. |journal=Gene |volume=341 |issue= |pages= 181–8 |year= 2005 |pmid= 15474300 |doi= 10.1016/j.gene.2004.06.043
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=O'Byrne SM, Wongsiriroj N, Libien J, "et al." |title=Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35647–57 |year= 2005 |pmid= 16115871 |doi= 10.1074/jbc.M507924200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Xue L, Jahng WJ, Gollapalli D, Rando RR |title=Palmitoyl transferase activity of lecithin retinol acyl transferase. |journal=Biochemistry |volume=45 |issue= 35 |pages= 10710–8 |year= 2006 |pmid= 16939223 |doi= 10.1021/bi060897y
*cite journal | author=Sénéchal A, Humbert G, Surget MO, "et al." |title=Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis. |journal=Am. J. Ophthalmol. |volume=142 |issue= 4 |pages= 702–4 |year= 2006 |pmid= 17011878 |doi= 10.1016/j.ajo.2006.04.057

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • LRat — Landrat EN district administrator; legislative body of certain cantons (Sw.) …   Abkürzungen und Akronyme in der deutschsprachigen Presse Gebrauchtwagen

  • Lecithin-Retinol-Acyltransferase — Masse/Länge Primärstruktur 230 Aminosäuren …   Deutsch Wikipedia

  • Cycle visuel — Le cycle de la vision est régi par la photoisomérisation du rétinal. Lorsque le rétinal 11 cis absorbe un photon, il passe de l´état 11 cis à l´état tout trans. Cette isomérisation est à l´origine de l´influx nerveux par phototransduction. Le… …   Wikipédia en Français

  • Visual phototransduction — is a process by which light is converted into electrical signals in the rod cells, cone cells and photosensitive ganglion cells of the retina of the eye.The visual cycle is the biological conversion of a photon into an electrical signal in the… …   Wikipedia

  • Otomat — Otomat/Teseo Type Medium range anti ship missile Service history …   Wikipedia

  • Bleach and recycle — The bleach and recycle process is utilized within the retina to ensure that the chromophore, 11 cis retinal, is present within opsin molecules in sufficient quantities to allow phototransduction to occur. To understand the process, we must look… …   Wikipedia

  • Glossary of military abbreviations — List of terms, acronyms, information, related to modern armour, artillery, infantry, weapons, and related military subject matter.* AA anti aircraft * AAA anti aircraft artillery Triple A * AAAV Advanced Amphibious Assault Vehicle * AAD Armoured… …   Wikipedia

  • Polysialic-acid O-acetyltransferase — In enzymology, a polysialic acid O acetyltransferase (EC number|2.3.1.136) is an enzyme that catalyzes the chemical reaction:acetyl CoA + an alpha 2,8 linked polymer of sialic acid ightleftharpoons CoA + polysialic acid acetylated on O 7 or O… …   Wikipedia

  • RPE65 — Retinal pigment epithelium specific protein 65kDa, also known as RPE65, is a human gene.cite web | title = Entrez Gene: RPE65 retinal pigment epithelium specific protein 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Rösrath — Wappen Deutschlandkarte …   Deutsch Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”