AKAP1

A kinase (PRKA) anchor protein 1, also known as AKAP1, is a human gene.cite web | title = Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8165| accessdate = ]

PBB_Summary
section_title =
summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.cite web | title = Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8165| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=
*cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801
*cite journal | author=Lin RY, Moss SB, Rubin CS |title=Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. |journal=J. Biol. Chem. |volume=270 |issue= 46 |pages= 27804–11 |year= 1996 |pmid= 7499250 |doi=
*cite journal | author=Trendelenburg G, Hummel M, Riecken EO, Hanski C |title=Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 313–9 |year= 1996 |pmid= 8769136 |doi= 10.1006/bbrc.1996.1172
*cite journal | author=Huang LJ, Durick K, Weiner JA, "et al." |title=Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 8057–64 |year= 1997 |pmid= 9065479 |doi=
*cite journal | author=Huang LJ, Wang L, Ma Y, "et al." |title=NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. |journal=J. Cell Biol. |volume=145 |issue= 5 |pages= 951–9 |year= 1999 |pmid= 10352013 |doi=
*cite journal | author=Herberg FW, Maleszka A, Eide T, "et al." |title=Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. |journal=J. Mol. Biol. |volume=298 |issue= 2 |pages= 329–39 |year= 2000 |pmid= 10764601 |doi= 10.1006/jmbi.2000.3662
*cite journal | author=Steen RL, Martins SB, Taskén K, Collas P |title=Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. |journal=J. Cell Biol. |volume=150 |issue= 6 |pages= 1251–62 |year= 2000 |pmid= 10995432 |doi=
*cite journal | author=Furusawa M, Ohnishi T, Taira T, "et al." |title=AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36647–51 |year= 2001 |pmid= 11483602 |doi= 10.1074/jbc.M103885200
*cite journal | author=Razani B, Lisanti MP |title=Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 4 |pages= C1241–50 |year= 2001 |pmid= 11546661 |doi=
*cite journal | author=Yukitake H, Furusawa M, Taira T, "et al." |title=AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45480–92 |year= 2003 |pmid= 12223483 |doi= 10.1074/jbc.M206201200
*cite journal | author=Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H |title=AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50885–92 |year= 2003 |pmid= 12414807 |doi= 10.1074/jbc.M206387200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Carlson CR, Ruppelt A, Taskén K |title=A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. |journal=J. Mol. Biol. |volume=327 |issue= 3 |pages= 609–18 |year= 2003 |pmid= 12634056 |doi=
*cite journal | author=Steen RL, Beullens M, Landsverk HB, "et al." |title=AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. |journal=J. Cell. Sci. |volume=116 |issue= Pt 11 |pages= 2237–46 |year= 2004 |pmid= 12697839 |doi= 10.1242/jcs.00432
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Cardone L, Carlucci A, Affaitati A, "et al." |title=Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 4613–26 |year= 2004 |pmid= 15143158 |doi= 10.1128/MCB.24.11.4613-4626.2004
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101

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