TIMP4

TIMP metallopeptidase inhibitor 4, also known as TIMP4, is a human gene.cite web | title = Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7079| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.cite web | title = Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7079| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Greene J, Wang M, Liu YE, "et al." |title=Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30375–80 |year= 1997 |pmid= 8939999 |doi=
*cite journal | author=Bigg HF, Shi YE, Liu YE, "et al." |title=Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15496–500 |year= 1997 |pmid= 9182583 |doi=
*cite journal | author=Olson TM, Hirohata S, Ye J, "et al." |title=Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. |journal=Genomics |volume=51 |issue= 1 |pages= 148–51 |year= 1998 |pmid= 9693046 |doi= 10.1006/geno.1998.5362
*cite journal | author=Pohar N, Godenschwege TA, Buchner E |title=Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human. |journal=Genomics |volume=57 |issue= 2 |pages= 293–6 |year= 1999 |pmid= 10198170 |doi= 10.1006/geno.1999.5776
*cite journal | author=Hernandez-Barrantes S, Shimura Y, Soloway PD, "et al." |title=Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 1 |pages= 126–30 |year= 2001 |pmid= 11178970 |doi= 10.1006/bbrc.2001.4323
*cite journal | author=Huang W, Li WQ, Dehnade F, Zafarullah M |title=Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage. |journal=J. Cell. Biochem. |volume=85 |issue= 2 |pages= 295–303 |year= 2002 |pmid= 11948685 |doi=
*cite journal | author=Zhang J, Cao YJ, Zhao YG, "et al." |title=Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3. |journal=Mol. Hum. Reprod. |volume=8 |issue= 7 |pages= 659–66 |year= 2003 |pmid= 12087081 |doi=
*cite journal | author=Kai HS, Butler GS, Morrison CJ, "et al." |title=Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48696–707 |year= 2003 |pmid= 12374789 |doi= 10.1074/jbc.M209177200
*cite journal | author=Radomski A, Jurasz P, Sanders EJ, "et al." |title=Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets. |journal=Br. J. Pharmacol. |volume=137 |issue= 8 |pages= 1330–8 |year= 2003 |pmid= 12466243 |doi= 10.1038/sj.bjp.0704936
*cite journal | author=Troeberg L, Tanaka M, Wait R, "et al." |title=E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). |journal=Biochemistry |volume=41 |issue= 50 |pages= 15025–35 |year= 2003 |pmid= 12475252 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chegini N, Rhoton-Vlasak A, Williams RS |title=Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding. |journal=Fertil. Steril. |volume=80 |issue= 3 |pages= 564–70 |year= 2003 |pmid= 12969699 |doi=
*cite journal | author=Zhao YG, Xiao AZ, Park HI, "et al." |title=Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 590–8 |year= 2004 |pmid= 14744773 |doi=
*cite journal | author=Pilka R, Domanski H, Hansson S, "et al." |title=Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26. |journal=Mol. Hum. Reprod. |volume=10 |issue= 9 |pages= 641–50 |year= 2005 |pmid= 15273280 |doi= 10.1093/molehr/gah092
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lee MH, Rapti M, Murphy G |title=Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 15967-75 |year= 2005 |pmid= 15713681 |doi= 10.1074/jbc.M500897200
*cite journal | author=Lizarraga F, Espinosa M, Maldonado V, Melendez-Zajgla J |title=Tissue inhibitor of metalloproteinases-4 is expressed in cervical cancer patients. |journal=Anticancer Res. |volume=25 |issue= 1B |pages= 623–7 |year= 2005 |pmid= 15816637 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Koskivirta I, Rahkonen O, Mäyränpää M, "et al." |title=Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology. |journal=Histochem. Cell Biol. |volume=126 |issue= 3 |pages= 335–42 |year= 2007 |pmid= 16521002 |doi= 10.1007/s00418-006-0163-8
*cite journal | author=Pilka R, Noskova V, Domanski H, "et al." |title=Endometrial TIMP-4 mRNA is expressed in the stroma, while TIMP-4 protein accumulates in the epithelium and is released to the uterine fluid. |journal=Mol. Hum. Reprod. |volume=12 |issue= 8 |pages= 497–503 |year= 2006 |pmid= 16809379 |doi= 10.1093/molehr/gal055

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