TRIM37

Tripartite motif-containing 37, also known as TRIM37, is a human gene.cite web | title = Entrez Gene: TRIM37 tripartite motif-containing 37| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4591| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.cite web | title = Entrez Gene: TRIM37 tripartite motif-containing 37| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4591| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Avela K, Lipsanen-Nyman M, Perheentupa J, "et al." |title=Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis. |journal=Am. J. Hum. Genet. |volume=60 |issue= 4 |pages= 896–902 |year= 1997 |pmid= 9106536 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Avela K, Lipsanen-Nyman M, Idänheimo N, "et al." |title=Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 298–301 |year= 2000 |pmid= 10888877 |doi= 10.1038/77053
*cite journal | author=Zapata JM, Pawlowski K, Haas E, "et al." |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Lehesjoki AE, Reed VA, Mark Gardiner R, Greene ND |title=Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis. |journal=Mech. Dev. |volume=108 |issue= 1-2 |pages= 221–5 |year= 2002 |pmid= 11578880 |doi=
*cite journal | author=Kallijärvi J, Avela K, Lipsanen-Nyman M, "et al." |title=The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1215–28 |year= 2002 |pmid= 11938494 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jagiello P, Hammans C, Wieczorek S, "et al." |title=A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. |journal=Hum. Mutat. |volume=21 |issue= 6 |pages= 630–5 |year= 2003 |pmid= 12754710 |doi= 10.1002/humu.10220
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hämäläinen RH, Avela K, Lambert JA, "et al." |title=Novel mutations in the TRIM37 gene in Mulibrey Nanism. |journal=Hum. Mutat. |volume=23 |issue= 5 |pages= 522 |year= 2004 |pmid= 15108285 |doi= 10.1002/humu.9233
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kallijärvi J, Lahtinen U, Hämäläinen R, "et al." |title=TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. |journal=Exp. Cell Res. |volume=308 |issue= 1 |pages= 146–55 |year= 2005 |pmid= 15885686 |doi= 10.1016/j.yexcr.2005.04.001
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Karlberg N, Jalanko H, Kallijärvi J, "et al." |title=Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37. |journal=Diabetes |volume=54 |issue= 12 |pages= 3577–81 |year= 2006 |pmid= 16306379 |doi=
*cite journal | author=Hämäläinen RH, Joensuu T, Kallijärvi J, Lehesjoki AE |title=Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing. |journal=Gene |volume=366 |issue= 1 |pages= 180–8 |year= 2006 |pmid= 16310976 |doi= 10.1016/j.gene.2005.08.008
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Hämäläinen RH, Mowat D, Gabbett MT, "et al." |title=Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. |journal=Clin. Genet. |volume=70 |issue= 6 |pages= 473–9 |year= 2007 |pmid= 17100991 |doi= 10.1111/j.1399-0004.2006.00700.x
*cite journal | author=Doğanc T, Yüksel Konuk BE, Alpan N, "et al." |title=A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy. |journal=Clin. Dysmorphol. |volume=16 |issue= 3 |pages= 173–6 |year= 2007 |pmid= 17551331 |doi= 10.1097/MCD.0b013e3280f6d00b

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