DCD (gene)

Dermcidin, also known as DCD, is a human gene.cite web | title = Entrez Gene: DCD dermcidin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117159| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.cite web | title = Entrez Gene: DCD dermcidin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117159| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Todorov P, Cariuk P, McDevitt T, "et al." |title=Characterization of a cancer cachectic factor. |journal=Nature |volume=379 |issue= 6567 |pages= 739–42 |year= 1996 |pmid= 8602222 |doi= 10.1038/379739a0
*cite journal | author=Todorov PT, Deacon M, Tisdale MJ |title=Structural analysis of a tumor-produced sulfated glycoprotein capable of initiating muscle protein degradation. |journal=J. Biol. Chem. |volume=272 |issue= 19 |pages= 12279–88 |year= 1997 |pmid= 9139670 |doi=
*cite journal | author=Cunningham TJ, Hodge L, Speicher D, "et al." |title=Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin. |journal=J. Neurosci. |volume=18 |issue= 18 |pages= 7047–60 |year= 1998 |pmid= 9736629 |doi=
*cite journal | author=Cunningham TJ, Jing H, Wang Y, Hodge L |title=Calreticulin binding and other biological activities of survival peptide Y-P30 including effects of systemic treatment of rats. |journal=Exp. Neurol. |volume=163 |issue= 2 |pages= 457–68 |year= 2000 |pmid= 10833321 |doi= 10.1006/exnr.2000.7390
*cite journal | author=Schittek B, Hipfel R, Sauer B, "et al." |title=Dermcidin: a novel human antibiotic peptide secreted by sweat glands. |journal=Nat. Immunol. |volume=2 |issue= 12 |pages= 1133–7 |year= 2001 |pmid= 11694882 |doi= 10.1038/ni732
*cite journal | author=Cunningham TJ, Jing H, Akerblom I, "et al." |title=Identification of the human cDNA for new survival/evasion peptide (DSEP): studies in vitro and in vivo of overexpression by neural cells. |journal=Exp. Neurol. |volume=177 |issue= 1 |pages= 32–9 |year= 2002 |pmid= 12429208 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Porter D, Weremowicz S, Chin K, "et al." |title=A neural survival factor is a candidate oncogene in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10931–6 |year= 2003 |pmid= 12953101 |doi= 10.1073/pnas.1932980100
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Monitto CL, Dong SM, Jen J, Sidransky D |title=Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia. |journal=Clin. Cancer Res. |volume=10 |issue= 17 |pages= 5862–9 |year= 2005 |pmid= 15355918 |doi= 10.1158/1078-0432.CCR-04-0435
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lai YP, Peng YF, Zuo Y, "et al." |title=Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 243–50 |year= 2005 |pmid= 15670776 |doi= 10.1016/j.bbrc.2004.12.143
*cite journal | author=Rieg S, Steffen H, Seeber S, "et al." |title=Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. |journal=J. Immunol. |volume=174 |issue= 12 |pages= 8003–10 |year= 2005 |pmid= 15944307 |doi=
*cite journal | author=Watchorn TM, Dowidar N, Dejong CH, "et al." |title=The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes. |journal=Int. J. Oncol. |volume=27 |issue= 4 |pages= 1105–11 |year= 2006 |pmid= 16142329 |doi=
*cite journal | author=Baechle D, Flad T, Cansier A, "et al." |title=Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L. |journal=J. Biol. Chem. |volume=281 |issue= 9 |pages= 5406–15 |year= 2006 |pmid= 16354654 |doi= 10.1074/jbc.M504670200
*cite journal | author=Lowrie AG, Wigmore SJ, Wright DJ, "et al." |title=Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. |journal=Br. J. Cancer |volume=94 |issue= 11 |pages= 1663–71 |year= 2006 |pmid= 16685272 |doi= 10.1038/sj.bjc.6603148
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Frum R, Busby SA, Ramamoorthy M, "et al." |title=HDM2-binding partners: interaction with translation elongation factor EF1alpha. |journal=J. Proteome Res. |volume=6 |issue= 4 |pages= 1410–7 |year= 2007 |pmid= 17373842 |doi= 10.1021/pr060584p
*cite journal | author=Lee Motoyama JP, Kim-Motoyama H, Kim P, "et al." |title=Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 4 |pages= 828–33 |year= 2007 |pmid= 17448443 |doi= 10.1016/j.bbrc.2007.03.112

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