HYOU1

Hypoxia up-regulated 1, also known as HYOU1, is a human gene.cite web | title = Entrez Gene: HYOU1 hypoxia up-regulated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10525| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the heat shock protein 70 family. This gene has three mRNAs from the use of alternative transcription sites. A cis-acting segment is found at the 5' end of exon 1A which is involved in the stress-dependent induction. The transcript that begins with exon 1B is preferentially induced by hypoxia, resulting in the accumulation of this protein in the endoplasmic reticulum (ER). The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. There is also an alternative translation site of this gene which lacks the signal peptide. This signal peptide-lacking protein, is only 3 amino acids shorter than the mature protein in the ER, and it is thought to have a housekeeping function in the cytosol.cite web | title = Entrez Gene: HYOU1 hypoxia up-regulated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10525| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Tsukamoto Y, Kuwabara K, Hirota S, "et al." |title=150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein. |journal=J. Clin. Invest. |volume=98 |issue= 8 |pages= 1930–41 |year= 1996 |pmid= 8878445 |doi=
*cite journal | author=Kuznetsov G, Chen LB, Nigam SK |title=Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 3057–63 |year= 1997 |pmid= 9006956 |doi=
*cite journal | author=Ikeda J, Kaneda S, Kuwabara K, "et al." |title=Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. |journal=Biochem. Biophys. Res. Commun. |volume=230 |issue= 1 |pages= 94–9 |year= 1997 |pmid= 9020069 |doi= 10.1006/bbrc.1996.5890
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Tsukamoto Y, Kuwabara K, Hirota S, "et al." |title=Expression of the 150-kd oxygen-regulated protein in human breast cancer. |journal=Lab. Invest. |volume=78 |issue= 6 |pages= 699–706 |year= 1998 |pmid= 9645760 |doi=
*cite journal | author=Ozawa K, Kuwabara K, Tamatani M, "et al." |title=150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6397–404 |year= 1999 |pmid= 10037731 |doi=
*cite journal | author=Bando Y, Ogawa S, Yamauchi A, "et al." |title=150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. |journal=Am. J. Physiol., Cell Physiol. |volume=278 |issue= 6 |pages= C1172–82 |year= 2000 |pmid= 10837345 |doi=
*cite journal | author=Kaneda S, Yura T, Yanagi H |title=Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. |journal=J. Biochem. |volume=128 |issue= 3 |pages= 529–38 |year= 2000 |pmid= 10965054 |doi=
*cite journal | author=Tamatani M, Matsuyama T, Yamaguchi A, "et al." |title=ORP150 protects against hypoxia/ischemia-induced neuronal death. |journal=Nat. Med. |volume=7 |issue= 3 |pages= 317–23 |year= 2001 |pmid= 11231630 |doi= 10.1038/85463
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827
*cite journal | author=Bando Y, Tsukamoto Y, Katayama T, "et al." |title=ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. |journal=FASEB J. |volume=18 |issue= 12 |pages= 1401–3 |year= 2005 |pmid= 15240565 |doi= 10.1096/fj.03-1161fje
*cite journal | author=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931–40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a
*cite journal | author=Lewandrowski U, Moebius J, Walter U, Sickmann A |title=Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. |journal=Mol. Cell Proteomics |volume=5 |issue= 2 |pages= 226–33 |year= 2006 |pmid= 16263699 |doi= 10.1074/mcp.M500324-MCP200
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Cechowska-Pasko M, Bankowski E, Chene P |title=The effect of hypoxia on the expression of 150 kDa oxygen-regulated protein (ORP 150) in HeLa cells. |journal=Cell. Physiol. Biochem. |volume=17 |issue= 1-2 |pages= 89–96 |year= 2006 |pmid= 16543725 |doi= 10.1159/000091467
*cite journal | author=Takeuchi S |title=Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. |journal=Protein J. |volume=25 |issue= 7-8 |pages= 517–28 |year= 2007 |pmid= 17131193 |doi= 10.1007/s10930-006-9038-z
*cite journal | author=Kitao Y, Matsuyama T, Takano K, "et al." |title=Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity? |journal=Antioxid. Redox Signal. |volume=9 |issue= 5 |pages= 589–95 |year= 2007 |pmid= 17330988 |doi= 10.1089/ars.2006.1518
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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